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MetabolomicsGut Microbiota-Mediated Tryptophan Metabolism Plays Dual Effects in Diffuse Large B-Cell Lymphoma via Regulating 3-IAA/5-HTP Balance and Antitumor Immunity
Timing-dependent tryptophan diets differentially modulate DLBCL outcomes via microbiota-derived 3-IAA (pre-inoculation, anti-tumor) versus 5-HTP (post-inoculation, pro-tumor), with pectin restoring microbial balance to enable a timed tryptophan-pectin precision nutrition strategy for enhanced immuno...
2026-09-07 | MTBLS15570 | MetaboLights
MetabolomicsNano-formulated bisphosphonate adjuvants simultaneously induce humoral and cellular immunity
Adjuvant is an important component of vaccines However, given the limitation of existing adjuvants in variety and mechanism, developing a unique and effective adjuvant is urgently needed for clinal applications. Recent studies have implicated that the mevalonate pathway plays an essential role in va...
2026-03-03 | MTBLS11696 | MetaboLights
MetabolomicsMicrobial metabolites calibrate innate immunity upon systemic viral infection

Gut microbiome dysbiosis is often associated with immune-mediated diseases. Here, we used germ-free (GF) mice, the synthetic minimal consortium OMM12, and specific pathogen-free (SPF) mice to dissect the causal influence of the microbiome on anti-viral immunity. The lack of microbial diversity af...

2026-08-01 | MTBLS7382 | MetaboLights
MetabolomicsCeramide Disrupts TM9SF2-PGK1 Axis to Redirect PD-L1 Trafficking and Enhance Antitumor Immunity

The PD-1/PD-L1 axis represents a cornerstone of cancer immunotherapy, yet the dynamic shuttling of PD-L1 between endosomal recycling and lysosomal degradation routes limits durable responses. Using a CRISPR screen targeting glycosphingolipid metabolism, we identify TM9SF2 as a key regulator of PD...

2026-02-05 | MTBLS13838 | MetaboLights
MetabolomicsViral-Induced Heme Accumulation Subverts TLR4bb-Mediated Antiviral Immunity by Triggering Gut Microbiota Dysbiosis, Metabolic Dysregulation, and Ferroptosis

This study identifies grass carp TLR4bb as a crucial hub coordinating antiviral immunity with heme metabolism, redox balance, and gut microbiota during GCRV-II infection. While TLR4bb recruits TIRAP/MyD88/TRIF to activate IFN signaling against the virus, its synergy with heme and viral sensing tr...

2026-01-23 | MTBLS13755 | MetaboLights
MetabolomicsPharmacological Targeting of ALDH1a2 in Dendritic Cells Enhances Antigen Presentation, T Cell Activation and Anti-tumor immunity
Dendritic cell (DC) vaccines have been proposed as cancer immunotherapies due to their role as crucial antigen-presenting cells that regulate T cell functions. Despite considerable efforts to optimize ex vivo priming of DCs, DC vaccines have rarely been successful, suggesting the presence of unknown...
2025-11-03 | MTBLS10389 | MetaboLights
TranscriptomicsHuman keratinocytes have a response to injury that upregulates CCL20 and other genes linking innate and adaptive immunity
In the early stages of wound healing, keratinocytes become “activated” and release inflammatory molecules such as interleukin-1 and interleukin-8 that are linked to innate immune responses and neutrophil recruitment. It is unclear, however, whether keratinocytes release molecules linked to adaptive ...
ORGANISM(S): Homo sapiens 
2011-09-19 | E-GEOD-30355 | biostudies-arrayexpress
GenomicsMAIT cells regulate NK cell mediated tumor immunity (NanoString)
MAIT cells regulate NK cell mediated tumor immunity (NanoString)
PRJNA742403 | ENA
GenomicsMAIT cells regulate NK cell mediated tumor immunity (RNA-Seq)
MAIT cells regulate NK cell mediated tumor immunity (RNA-Seq)
PRJNA742401 | ENA
GenomicsMHC Class I on Target Cells Regulates CD4+ T cell-mediated Immunity
MHC Class I on Target Cells Regulates CD4+ T cell-mediated Immunity
PRJNA1405593 | ENA
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