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GenomicsTranscriptomic Cell Type Specificity of Local Cortical Circuits
Transcriptomic Cell Type Specificity of Local Cortical Circuits
PRJNA1086941 | ENA
TranscriptomicsCas9 target DNA specificity in vitro and in vivo (S. cerevisiae)
Cas9, a CRISPR RNA-guided nuclease, has been rapidly adopted as a tool for biochemical and genetic manipulation of DNA. Although Cas9 offers remarkable specificity and versatility for genome manipulation, mis-targeted events occur. To extend the understanding of Cas9 target::homology requirements, w...
ORGANISM(S): synthetic construct 
2016-06-10 | E-GEOD-79667 | biostudies-arrayexpress
GenomicsAsymmetry of STAT action in driving IL-27 and IL-6 transcriptional outputs and cytokine specificity
IL-6 and IL-27 have antagonistic and overlapping functions, signal through a shared receptor subunit and employ the same downstream STAT proteins. To evaluate the degree of specificity and redundancy for these cytokines, we quantified global transcriptomic changes induced by the two cytokines and de...
ORGANISM(S): Mus musculus 
2015-05-27 | E-GEOD-65621 | biostudies-arrayexpress
TranscriptomicsCell type specificity of chromatin organization mediated by CTCF and cohesin
CTCF sites are abundant in the genomes of diverse species but their function is enigmatic. We used chromosome conformation capture to determine long-range interactions among CTCF/cohesin sites over 2 Mb on human chromosome 11 encompassing the β-globin locus and flanking olfactory receptor genes. Alt...
ORGANISM(S): Homo sapiens 
2011-01-13 | E-GEOD-26507 | biostudies-arrayexpress
TranscriptomicsResponsiveness of genes to manipulation of transcription factors in ES cells is associated with chromatin structure and tissue specificity
Background: In addition to determining static states of gene expression (high vs. low), it is important to characterize their dynamic status. For example, genes with H3K27me3 chromatin marks are not only suppressed but also poised for activation. However, the responsiveness of genes to perturbations...
ORGANISM(S): Mus musculus 
2011-02-14 | E-GEOD-22151 | biostudies-arrayexpress
TranscriptomicsRNA-seq reveals that Air1 and Air2 control TRAMP substrate specificity for nuclear RNA surveillance
The Saccharomyces cerevisiae TRAMP4 and TRAMP5 complexes, which consist of the poly(A) polymerase Trf4 or Trf5, respectively, the zinc knuckle proteins Air1 or Air2, and the RNA helicase Mtr4, play a critical role in nuclear RNA surveillance. Although it is known to enhance the nuclease activity of ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-11-14 | E-GEOD-42231 | biostudies-arrayexpress
GenomicsHIFa isoform specific activation drives cell-type specificity of VHL-associated oncogenesis
HIFa isoform specific activation drives cell-type specificity of VHL-associated oncogenesis
PRJNA1190947 | ENA
TranscriptomicsResponsiveness of genes to manipulation of transcription factors in ES cells is associated with histone modifications and tissue specificity (2 of 2)
BACKGROUND: In addition to determining static states of gene expression (high vs. low), it is important to characterize their dynamic status. For example, genes with H3K27me3 chromatin marks are not only suppressed but also poised for activation. However, the responsiveness of genes to perturbations...
ORGANISM(S): Mus musculus 
2011-02-11 | E-GEOD-19814 | biostudies-arrayexpress
TranscriptomicsThe tinkerbell (tink) mutation identifies the dual-specificity MAPK phosphatase INDOLE-3-BUTYRIC ACID-RESPONSE5 (IBR5) as a novel regulator of organ size in Arabidopsis.
Mitogen-activated dual-specificity MAPK phosphatases are important negative regulators in the MAPK signalling pathways responsible for many essential processes in plants. In a screen for mutants with reduced organ size we have identified a mutation in the active site of the dual-specificity MAPK ph...
ORGANISM(S): Arabidopsis thaliana 
2015-07-30 | E-GEOD-66419 | biostudies-arrayexpress
TranscriptomicsUNG shapes the specificity of AID-induced somatic hypermutation
This SuperSeries is composed of the following subset Series: GSE39108: UNG shapes the specifity of AID-induced somatic hypermutation in non B cells GSE39114: UNG shapes the specifity of AID-induced somatic hypermutation in B cells Refer to individual Series
ORGANISM(S): Mus musculus 
2012-07-04 | E-GEOD-39115 | biostudies-arrayexpress
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