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MetabolomicsHorizontal Transfer of Bacteriocin Biosynthesis Genes Requires Metabolic Adaptation To Improve Compound Production and Cellular Fitness

Biosynthetic gene clusters (BGCs) encoding the production of bacteriocins are widespread among bacterial isolates and are important genetic determinants of competitive fitness within a given habitat. Staphylococci produce a tremendous diversity of compounds, and the corresponding BGCs are frequen...

2022-11-09 | MTBLS5196 | MetaboLights
TranscriptomicsMassively parallel interrogation of the effects of gene expression levels on cellular fitness
Data of gene expression levels across individuals, cell types, and disease states is rapidly expanding, yet we have limited understanding of how expression levels impact cellular and organismal phenotypes. Here, we present a massively parallel system for assaying the effect of gene expression levels...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-25 | E-GEOD-83936 | biostudies-arrayexpress
ProteomicsStaphylococcal ClpXP protease targets the cellular antioxidant system to eliminate fitness-compromised cells in stationary phase
The transition from growth to stationary phase is a natural response of bacteria to starvation and stress. When stress is alleviated and more favorable growth conditions return, bacteria resume proliferation without a significant loss in fitness. Although specific adaptations that enhance the persis...
ORGANISM(S): Staphylococcus aureus 
2022-05-19 | PXD029457 | Pride
Clpx Soda Stationary phase Clpp Competitive fitness Staphylococcus aureus Cell death 
ProteomicsMassively parallel fitness profiling reveals multiple novel enzymes in Pseudomonas putida lysine metabolism
The lysine metabolism of Pseudomonas putida can produce multiple important commodity chemicals and is implicated in rhizosphere colonization. However, despite intensive study, the biochemical and genetic links between lysine metabolism and central metabolism remains unresolved in P. putida. Here, we...
ORGANISM(S): Pseudomonas Putida Kt2440 
PXD011350 | panorama
TranscriptomicsGenetic variation in parthenogenetic collembolans is associated with differences in fitness and cadmium-induced transcriptome responses
Ecotoxicological tests may be biased by the use of laboratory strains that usually contain very limited genetic diversity. It is therefore essential to study how genetic variation influences stress tolerance relevant for toxicity outcomes. To that end we studied sensitivity to cadmium in two distinc...
ORGANISM(S): Folsomia candida 
2012-12-21 | E-GEOD-34167 | biostudies-arrayexpress
ModelsWest2019 - Cellular interactions constrain tumor growth
These selections of models are described in the paper: Cellular interactions constrain tumor growth by Jeffrey West and Paul K. Newton Significance: A mathematical model relating tumor heterogeneity at the cellular level to tumor growth at the macroscopic level is described based on a statistical m...
2024-09-02 | BIOMD0000000820 | BioModels
TranscriptomicsComparison of salt stress resistance genes in transgenic Arabidopsis thaliana indicates that extent of transcriptomic change may not predict secondary phenotypic or fitness effects
Engineered abiotic stress resistance is an important target for increasing agricultural productivity.There are concerns, however, regarding possible ecological impacts of transgenic crops. In contrast to the first wave of transgenic crops, many abiotic stress resistance genes can initiate complex do...
ORGANISM(S): Arabidopsis thaliana 
2011-10-05 | E-GEOD-26983 | biostudies-arrayexpress
GenomicsBCL6 reinforces brown adipocyte cellular identity to preserve thermogenic fitness
BCL6 reinforces brown adipocyte cellular identity to preserve thermogenic fitness
PRJNA506236 | ENA
GenomicsMetabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species
Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species
PRJNA663327 | ENA
TranscriptomicsFitness Landscape of Antibiotic Tolerance in Pseudomonas aeruginosa Biofilms
Bacteria in biofilms have higher antibiotic tolerance than their planktonic counterparts. A major outstanding question is the degree to which the biofilm-specific cellular state and its constituent genetic determinants contribute to this hyper-tolerant phenotype. Here, using genome-wide functional...
ORGANISM(S): Pseudomonas aeruginosa 
2011-11-21 | E-GEOD-26142 | biostudies-arrayexpress
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