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MetabolomicsMulti-omic Analysis of ClpP Activation in Triple-Negative Breast Cancer Cells
Not available
ORGANISM(S): Homo sapiens 
ST002408 | MetabolomicsWorkbench
TranscriptomicsExpression data from mitochondrial protease ClpP knock-out mice.
The peptidase ClpP is conserved from bacteria to human. In the mitochondrial matrix, it multimerizes and forms a macromolecular proteasome-like cylinder. Because of its known relevance for the mitochondrial unfolded protein response during cell stress, we characterized two ClpP knock-out mouse found...
ORGANISM(S): Mus musculus 
2013-07-17 | E-GEOD-40207 | biostudies-arrayexpress
ProteomicsProteomics and phosphoproteomics analysis of SUM159 cells upon ClpP activation with ONC201 and TR57 compounds
ClpP activators ONC201 and related small molecules (TR compounds, Madera Therapeutics), have demonstrated significant anti-cancer potential in an array of in vitro and in vivo studies, including clinical trials for refractory solid tumors. Though progress has been made in identifying specific phenot...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038990 | Pride
Drug development Drug mechanism Cancer Clpp 
GenomicsBrucella sp. clpP delta
Brucella sp. clpP delta Genome sequencing
PRJNA562802 | ENA
ProteomicsMurine CLPP protease substrate trapping in MEF cells
Classic susbtrate-trapping screen for ClpXP substrates using MEF cell lines overexpressing FLAG-tagged CLPP (WT), proteolytically inactive CLPP (TRAP) or vector control (NEG)
ORGANISM(S): Mus musculus (Mouse) 
2020-06-01 | PXD015399 | Pride
Interactor Mouse Cllp protease Substrate Trap experiment Cell line 
ProteomicsMablango_ClpP_HYTANE_P124_Lumos
This dataset consists of 6 raw MS files, acquired on Thermo Fusion Lumos mass spectrometer operated in Data Dependent Acquisition mode. Samples were generated by Keith Wong. Sample processing and mass spectrometry acquisition was performed by Cassandra Wong. Data analysis was performed by Cassandra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-13 | MSV000089642 | MassIVE
ProteomicsBacillus subtilis ClpP degradome
To characterize the proteins substrates and the modifications of the ClpP protease of Bacillus subtilis.
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2016-10-10 | PXD003305 | Pride
Clpp Protein degradation Phosphoarginine 
GenomicsBrucella abortus strain:clpP
Brucella abortus strain:clpP Genome sequencing
PRJNA573837 | ENA
ProteomicsLegionella pneumophila life stage-specific proteins regulated via ClpP-dependent
To investigate the role of ClpP-mediated proteolysis in the regulation of life stage specific proteins of Legionella pneumophila, the bacteria in the RP/TP of WT and ΔclpP were collected and analyzed by mass spectrometry. To screen the substrates of ClpP during the whole life cycle, bacterial whole-...
ORGANISM(S): Legionella Pneumophila Subsp. Pneumophila Lp02 
2021-06-16 | PXD026737 |
ProteomicsiTRAQ analysis of ClpP mutant treated with methyl gallate
Methyl gallate (MG) is an effective microbicide with great potential usefulness in the integrated management of plant diseases and an important potential drug for clinical application. However, its target remains unknown. This study conducted a transposon sequencing (Tn-seq) under MG treatment in pl...
ORGANISM(S): Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum) 
2020-12-10 | PXD021102 | Pride
Methyl gallate Ralstonia solanacearum Clpp protease 
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