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MetabolomicsCell-to-cell heterogeneity drives host-virus coexistence in a bloom-forming alga

Algal blooms drive global biogeochemical cycles of key nutrients in the oceans and serve as hotspots for biological interactions. The massive spring blooms of the cosmopolitan coccolithophore Emiliania huxleyi (E. huxleyi) are often infected by the lytic Emiliania huxleyi

2024-01-04 | MTBLS1956 | MetaboLights
MetabolomicsSingle-cell time-resolved multi-omics reveal apoptotic and ferroptotic heterogeneity during foam cell formation

Macrophage-derived foam cell plays a pivotal role in the plaque formation and rupture during the progression of atherosclerosis. Foam cells are destined to divergent cell fate and functions in response to external stimuli based on their internal states, which however is hidden in the traditional ...

2023-09-08 | MTBLS6366 | MetaboLights
TranscriptomicsReactivation of multipotency by oncogenic PIK3CA induces breast tumor heterogeneity
Breast cancer is the most frequent cancer in women and consists of heterogeneous types of tumours that are classified into different histological and molecular subtypes1-3. Pik3ca and p53 are the two most frequently mutated genes and are associated with different types of human breast cancers4. The ...
ORGANISM(S): Mus musculus 
2015-08-13 | E-GEOD-69290 | biostudies-arrayexpress
TranscriptomicsGenetic Heterogeneity in Mouse Mammary Tumors
Human cancers result from a complex series of genetic alterations resulting in heterogeneous disease states. Dissecting this heterogeneity is critical for understanding underlying mechanisms and providing opportunities for therapeutics matching the complexity. Mouse models of cancer have generally b...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-15904 | biostudies-arrayexpress
TranscriptomicsCell cycle positioning drives heterogeneity within the pluripotent stem cell compartment
Heterogeneity in pluripotent cells marks a metastable state where cells may drift between native and lineage-primed populations. While the role for these heterogeneities are unclear, they may reflect the dynamic equilibriums of signaling networks and have a direct effect on differentiation potentia...
ORGANISM(S): Homo sapiens 
2013-12-19 | E-GEOD-53481 | biostudies-arrayexpress
TranscriptomicsMolecular heterogeneity in acute renal allograft rejection
The data set contains 67 array (lymphochip cDNA array), published in N Engl J Med 2003 Jul 10;349(2):125-38. PMID: 12853585. TITLE: Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. BACKGROUND: The causes and clinical course of acute rejection vary, a...
ORGANISM(S): Homo sapiens 
2003-07-01 | E-GEOD-343 | biostudies-arrayexpress
TranscriptomicsA Cell Epigenotype Specific Model for the Correction of Cellular Heterogeneity in the Brain
Cellular heterogeneity may bias cell type specific epigenetic patterns leading to a dramatic increase in false positive or negative findings in psychiatric epigenetic studies. To address this issue, we performed fluorescence activated cell sorting (FACS) of neuronal nuclei in post mortem frontal cor...
ORGANISM(S): Homo sapiens 
2013-02-22 | E-GEOD-41826 | biostudies-arrayexpress
GenomicsIntegrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics
The human placenta is a dynamic and cellular heterogeneous organ, which is critical in fetomaternal homeostasis and the development of preeclampsia. Previous work has shown that placenta-derived cell-free RNA increases during pregnancy. We applied large-scale microfluidic single-cell transcriptomic ...
EGAS00001002449 | EGA
ModelsWest2019 - Cellular interactions constrain tumor growth
These selections of models are described in the paper: Cellular interactions constrain tumor growth by Jeffrey West and Paul K. Newton Significance: A mathematical model relating tumor heterogeneity at the cellular level to tumor growth at the macroscopic level is described based on a statistical m...
2024-09-02 | BIOMD0000000820 | BioModels
TranscriptomicsLiquid Biopsy-Based Single-Cell Transcriptome Profiling Characterizes Heterogeneity of Disseminated Tumor Cells from Lung Adenocarcinoma
To decipher the heterogeneity and distinct molecular signatures of disseminated tumor cells, we profiled the transcriptomes single cells from malignant pleural effusion. RNA-seq was done using the standard 10x chromium v3 chemistry.
ORGANISM(S): Homo sapiens 
2020-09-01 | E-MTAB-8530 | biostudies-arrayexpress
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