Cellular target engagement

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Acidithiobacillus ferrooxidans ATCC 53993 (60)
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CHEBI ID

CHEBI:18314 (1)
CHEBI:18095 (1)
CHEBI:15611 (1)
CHEBI:16283 (1)
CHEBI:16977 (1)
CHEBI:15428 (1)
CHEBI:17196 (1)
CHEBI:17115 (1)
CHEBI:16467 (1)
CHEBI:18019 (1)
CHEBI:17203 (1)
CHEBI:18050 (1)
CHEBI:15971 (1)
CHEBI:16857 (1)
CHEBI:17053 (1)
CHEBI:16015 (1)
CHEBI:16414 (1)
CHEBI:17191 (1)
CHEBI:15603 (1)
CHEBI:16643 (1)
CHEBI:17895 (1)
CHEBI:17295 (1)
CHEBI:16828 (1)

Metabolite Name

(S)-Hexahydropyrrolo[1,2-a]pyrazine-1,4-dione (2)
Diisopropylamine (2)
1,10-Phenanthroline (2)
Ethyl isopropyl sulfide (2)
Methacrylamide (2)
(5Z,9Z,12Z)-octadeca-5,9,12-trienoic acid (2)
2-Hexenyl acetate (2)
1H-Imidazole-1-acetic acid (2)
N-Acetyl-Leu (2)
(2R,3R)-2-Aminooctadecane-1,3-diol (2)
Pyroglutamylproline (2)
Phenyl-Alanine (2)
D-Tyrosine (2)
1-Palmitoylphosphatidylcholine (2)
Rhodamine B (2)
2-Methylimidazole (2)
9-Arabinofuranosyladenine (2)
DL-Proline (2)
9,12-Octadecadiynoic acid (2)
Indoline (2)
2,4-Dimethylquinoline (2)
1-Cyclohexyl-4-(1,2-diphenylethyl)piperazine (2)
Baikiain (2)
Cis-Vitamin K1 (2)
9-beta-d-Arabinofuranosylguanine (2)
Di-N-propylamine (2)
Dieporeticanin (2)
Choline sulfate (2)
Octadeca-9,11-dienoic acid (2)
Furanone A (2)

First Public Date

2026 (15)
2025 (4)
2024 (4)
2019 (3)
2014 (2)
2023 (1)
2022 (1)
2021 (1)
2020 (1)

Modification

2x(15)N labeled L-lysine (1)
4x(15)N labeled L-arginine (1)

Study type

Transcription profiling by array (33)
ChIP-chip by tiling array (1)
DNA-seq (1)
RNA-seq of coding RNA (1)
RNA-seq of non coding RNA (1)

Release Date

2025 (77)
2022 (61)
2021 (59)
2023 (59)
2024 (57)
2020 (47)
2019 (29)
2018 (29)
2017 (29)
2016 (20)
2013 (20)
2015 (19)
2026 (13)
2012 (8)
2010 (8)
2008 (8)
2014 (7)
2011 (6)
2009 (4)
2003 (3)
2007 (2)
2004 (1)

Lab affiliation

Professor of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, The Netherlands (10)
Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India (2)
Department of Chemistry, Imperial College London, UK (2)
Laboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS, IPHC, UMR 7178, Strasbourg, France (2)
Queensland Brain Institute, The University of Queensland, St Lucia Campus (Brisbane), QLD 4072, Australia (2)
2Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), 1030 Vienna, Austria. (1)
Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia (1)
Biochemistry Department, Kavli Institute for Nanoscience Discovery, University of Oxford, UK (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, Utrecht 3584 CH, The Netherlands Netherlands Proteomics Center, Padualaan 8, Utrecht 3584 CH, The Netherlands (1)
Bristol Myers Squibb (1)
Caltech Division of Chemistry and Chemical Engineering (1)
Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK (1)
Cellzome - a GSK company (1)
Chair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Germany (1)
Chair of Proteomics and Bioanalytics, Technical University of Munich (1)
Chemical Biology Laboratory, National Cancer Institute (1)
Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India (1)
Department of Cell Biology, Harvard Medical School (1)
Department of Chemistry & Chemical biology, Northeastern University (1)
Dr. Roman Fischer Associate Professor and Head of Discovery Proteomics Facility University of Oxford Target Discovery Institute, NDMRB Roosevelt Drive Oxford, OX3 7FZ United Kingdom (1)
Drug Discovery Moffitt Cancer Center Tampa, FL, USA (1)
Genome Sciences, University of Washington, Seattle, WA (1)
Head Proteomics Group Leiden University Medical Center, Center for Proteomics and Metabolomics, PO Box 9600, Postal zone P1-Q, 2300 RC Leiden, The Netherlands (1)
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA Department of Medicine and Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA 94158, USA (1)
Imperial College London (1)
Indiana University School of Medicine (1)
Institute of Chemical Biology, Department of Chemistry, Imperial College London (1)
Institute of Molecular Biology (IMB), Mainz, Germany (1)
Institute of Virology - Viral Immunopathology, Faculty of Medicine, Technical University Munich (1)
Max Planck Institute for Moleclar Biomedicine Bioanalyticyl Mass Spectrometry Unit Röntgenstr. 20 48149 Münster Germany (1)

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Mechanistic profiling of Bifemetstrobin against the tea anthracnose pathogen and candidate evaluation of an amine oxidase target

Tea anthracnose caused by Glomerella cingulata threatens yield and quality, while resistance to legacy fungicides highlights the need for new modes of action. We characterized the antifungal activity and mechanism of bifemetstrobin against G. cingulata by combining efficacy assays with cell biology ...

2026-04-24 | MTBLS14357 | MetaboLights

Mechanistic profiling of Bifemetstrobin against the tea anthracnose pathogen and candidate evaluation of an amine oxidase target

2026-03-13 | MTBLS13992 | MetaboLights

A probe-based target engagement assay for kinases in live cells

Protein kinases are an important class of drug targets due to their crucial roles in almost every aspect of cellular function, such as cell growth, metabolism, proliferation, differentiation, migration, effector functions and cell death. Starting from the previously described covalent promiscuous ki...

ORGANISM(S): Homo sapiens (Human)

2025-04-07 | PXD047949 | Pride

Assessing target engagment using proteome-wide solvent shift assays

Recent advances in mass spectrometry (MS) have enabled quantitative proteomics to become a powerful tool in the field of drug discovery, especially when applied toward proteome-wide target engagement studies. Similar to temperature gradients, increasing concentrations of organic solvents stimulate u...

ORGANISM(S): Homo sapiens (Human)

2022-02-17 | PXD026297 | Pride

Target enagagement

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.

Not available

S-EPMC11624193 | biostudies-literature

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors.

Not available

S-EPMC8080703 | biostudies-literature

Rapid Evaluation of Small Molecule Cellular Target Engagement with a Luminescent Thermal Shift Assay.

Not available

S-EPMC8366000 | biostudies-literature