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Regulation of heart regeneration by LSD1 through suppressing CEND1
Epigenetic repression of Cend1 by LSD1 is essential for murine heart development
Background: Improving heart regeneration through reactivating cardiomyocyte proliferation holds a great potential for repairing diseased hearts. We recently reported that LSD1-dependent epigenetic repression of Cend1 transcription is prerequisite for cardiomyocyte proliferation and mouse heart devel...
ORGANISM(S): Mus musculus 
2025-05-31 | GSE296505 | GEO
Epigenetic regulation of heart development remains incompletely understood. Here we show that lysine-specific demethylase 1 (LSD1), a histone demethylase, critically controls cardiomyocyte proliferation during heart development. Cardiomyocyte-specific deletion of Lsd1 in mice inhibited cardiomyocyte...
ORGANISM(S): Mus musculus 
2023-10-30 | GSE244414 | GEO
To explore the underlying mechanisms of Cend1 in regulating mitochondrial functions and ATP production, immunoprecipitation combined with mass spectrometry (IP-MS) was performed to identify Cend1-interacting proteins in mitochondria by using Cend1 antibody and isolated protein lysate from WT and Cen...
ORGANISM(S): Mus Musculus 
2025-11-14 | PXD070715 |
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