Cenp - OmicsDI

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Unknown (865)
Genomics (363)
Transcriptomics (239)
Proteomics (136)
Other (17)
Metabolomics (6)
Methylation profiling (1)
Multiomics (1)

Organisms

Homo sapiens (173)
Mus musculus (84)
Schizosaccharomyces pombe (58)
Saccharomyces cerevisiae (24)
Drosophila melanogaster (11)
Rattus norvegicus (8)
Arabidopsis thaliana (6)
Bos taurus (6)
Caenorhabditis elegans (6)
Oryza sativa (5)
Zea mays (5)
Canis lupus familiaris (5)
Pneumocystis carinii (5)
Equus caballus (3)
Candida albicans (3)
Hoolock leuconedys (3)
Toxoplasma gondii (2)
Ascaris suum (2)
Xenopus laevis (2)
Pneumocystis murina (2)
Hylobates moloch (2)
Chamaelirium luteum (1)
Tetrahymena thermophila (1)
Taeniopygia guttata (1)
Catharanthus roseus (1)
Salmo salar (1)
Heterocephalus glaber (1)
Solanum lycopersicum (1)
Oryza sativa Japonica Group (1)
Triticum aestivum (1)

Organisms

Homo sapiens (47)
Schizosaccharomyces pombe (41)
Saccharomyces cerevisiae (8)
Gallus gallus (8)
Pneumocystis carinii (5)
Mus musculus (5)
Pneumocystis murina (2)
Saccharomyces cerevisiae S288C (2)
Pyricularia oryzae (2)
Drosophila melanogaster (2)
Caenorhabditis elegans (2)
Gasterosteus aculeatus (2)
Candida albicans (2)
Pneumocystis sp. 'macacae' (1)
Ascaris suum (1)
Xenopus borealis (1)
Phascolarctos cinereus (1)
Chlamydomonas reinhardtii (1)
Parascaris univalens (1)
Xenopus laevis (1)
Xenopus tropicalis (1)
Notamacropus eugenii (1)
Phytophthora sojae (1)
Phaeodactylum tricornutum (1)
Equus caballus (1)
Saccharomyces cerevisiae BY4741 (1)
Canis lupus familiaris (1)
Zea mays (1)
Sus scrofa (1)

Repository

biostudies-arrayexpress (270)
ENA (205)
geo (128)
MassIVE (77)
pride (29)
PeptideAtlas (23)
EGA (15)
MetaboLights (6)
jPOST (5)
PanoramaPublic (2)
iProX (1)
LINCS (1)
PAXDB (1)

Tissue

Others (10)
Cell culture (9)
Cell suspension culture (2)
Epithelial cell (2)
Peritoneal dialysis fluid (1)
Cell line cell (1)
HeLa cell (1)
Hepatocyte (1)
Permanent cell line cell (1)

Disease

Papillary renal cell carcinoma (1)
Early-life seizures (1)
Prostate cancer (1)
Liver cancer (1)
Disease free (1)

Technology Type

Mass Spectrometry (29)
Shotgun proteomics (10)
Chemical cross-linking coupled with mass spectrometry proteomics (9)
Mass spectrometry (6)
Affinity purification coupled with mass spectrometry proteomics (5)
Gel-based experiment (3)
Data-dependent acquisition (3)
Bottom-up proteomics (3)
454 GS FLX Titanium (1)
Illumina HiSeq 2500 (1)
Fluorescence intensity (1)
Fluorescence imaging (1)
Affinity proteomics (1)

Instrument Platform

LTQ Orbitrap Elite (18)
Illumina NovaSeq 6000 (14)
LTQ Orbitrap Velos (13)
Orbitrap Fusion Lumos (10)
Orbitrap Fusion (8)
Orbitrap Eclipse (7)
LTQ Orbitrap (7)
Illumina HiSeq 2500 (6)
Q Exactive (6)
6560 Q-TOF LC/MS (5)
NextSeq 2000 (4)
Illumina NovaSeq X (2)
DNBSEQ-T7 (2)
NextSeq 550 (2)
NextSeq 500 (2)
10X v3 (1)
Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (1)
MA900, Sony (1)
10x Chromium Controller (1)
Covaris, NEBNext Ultra II DNA library prep kit (1)
VersArray ChipReader [Bio-Rad Laboratories] (1)
AB SOLiD 4 System (1)
BAS-1800 [FUJIFILM] (1)
GenePix 4000A [Axon Instruments] (1)
GenePix 4000B [Axon Instruments] (1)
Ion Torrent Proton (1)
MinION (1)
Illumina MiSeq (1)
Illumina HiSeq 3000 (1)
Illumina HiSeq 4000 (1)

Publication Date

2013 (52)
2014 (50)
2015 (42)
2012 (36)
2016 (33)
2024 (29)
2023 (27)
2019 (26)
2018 (25)
2011 (25)
2026 (24)
2010 (24)
2022 (23)
2025 (21)
2021 (21)
2008 (21)
2020 (20)
2017 (11)
2007 (10)
2009 (8)
2006 (7)
2005 (3)
2004 (1)

UNIPROT ID/AC

YIDJ_ECOLI (1)
PHND_ECOLI (1)
FABR_ECOLI (1)
PPTA_ECOLI (1)
PTFLB_ECOLI (1)
IF2_ECOLI (1)
RL34_ECOLI (1)
MSRB_ECOLI (1)
MDH_ECOLI (1)
ARND_ECOLI (1)
RL31_ECOLI (1)
OMPN_ECOLI (1)
ECPC_ECOLI (1)
YRBG_ECOLI (1)
6PGD_ECOLI (1)
YGJQ_ECOLI (1)
NARZ_ECOLI (1)
NDPA_ECOLI (1)
FIMA1_ECOLI (1)
SLYA_ECOLI (1)
RL29_ECOLI (1)
ACRA_ECOLI (1)
G3P1_ECOLI (1)
LPTD_ECOLI (1)
DAPA_ECOLI (1)
RHLB_ECOLI (1)
LRP_ECOLI (1)
YDFZ_ECOLI (1)
YEBY_ECOLI (1)
EFP_ECOLI (1)

ENSEMBL ID

ENSG00000170477 (8)
ENSG00000147251 (3)
ENSG00000247315 (2)

CHEBI ID

CHEBI:86980 (2)
CHEBI:71720 (2)
CHEBI:141290 (2)
CHEBI:141288 (2)
CHEBI:136345 (2)
CHEBI:136382 (2)
CHEBI:134451 (2)
CHEBI:85870 (2)
CHEBI:136243 (2)
CHEBI:85693 (2)
CHEBI:71721 (2)
CHEBI:85700 (2)
CHEBI:85701 (2)
CHEBI:132039 (2)
CHEBI:132038 (2)
CHEBI:132035 (2)
CHEBI:132034 (2)
CHEBI:85743 (2)
CHEBI:85736 (2)
CHEBI:90302 (2)
CHEBI:84662 (2)
CHEBI:84665 (2)
CHEBI:85874 (2)
CHEBI:85726 (2)
CHEBI:90305 (2)
CHEBI:85725 (2)
CHEBI:66859 (2)
CHEBI:64523 (2)
CHEBI:64433 (2)
CHEBI:66857 (2)

Metabolite Name

Triacylglycerol 60:8 (1)
Triacylglycerol 60:7 (1)
Triacylglycerol 60:6 (1)
Triacylglycerol 60:5 (1)
Triacylglycerol 60:4 (1)
Triacylglycerol 60:3 (1)
Triacylglycerol 60:2 (1)
Triacylglycerol 60:1 (1)
Triacylglycerol 60:0 (1)
Triacylglycerol 58:8 (1)
Triacylglycerol 58:7 (1)
Triacylglycerol 58:6 (1)
Triacylglycerol 58:5 (1)
Triacylglycerol 58:4 (1)
Triacylglycerol 58:3 (1)
Triacylglycerol 58:2 (1)
Triacylglycerol 58:1 (1)
Triacylglycerol 58:0 (1)
Triacylglycerol 56:9 (1)
Triacylglycerol 56:8 (1)
Triacylglycerol 56:1 (1)
Triacylglycerol 56:0 (1)
Triacylglycerol 54:9 (1)
Triacylglycerol 54:8 (1)
Triacylglycerol 54:1 (1)
Triacylglycerol 54:0 (1)
Triacylglycerol 52:9 (1)
Triacylglycerol 52:8 (1)
Triacylglycerol 52:7 (1)
Triacylglycerol 50:8 (1)

First Public Date

2024 (25)
2019 (20)
2014 (20)
2026 (18)
2025 (18)
2022 (18)
2018 (13)
2013 (12)
2023 (11)
2021 (11)
2020 (11)
2016 (11)
2017 (8)
2015 (8)
2011 (1)

Classification

fungi (2)
helminths (1)

Study type

Transcription profiling by array (127)
ChIP-seq (49)
RNA-seq of coding RNA (23)
ChIP-chip by tiling array (16)
ChIP-chip by array (8)
RNA-seq of coding RNA from single cells (6)
Unknown experiment type (5)
Comparative genomic hybridization by array (5)
Methylation profiling by array (5)
Spatial transcriptomics by high-throughput sequencing (3)
DNA-seq (3)
Methylation profiling by high throughput sequencing (3)
RNA-seq of non coding RNA (3)
Transcription profiling by tiling array (2)
Other (2)
Transcription profiling by SAGE (1)
Plant - High-throughput sequencing (1)
Cell line - One-color microarray (1)
Cell line - High-throughput sequencing (1)
RNAi profiling by array (1)
Genotyping by array (1)
Single nucleus RNA sequencing (1)
MicroRNA profiling by array (1)
Proteomic profiling by array (1)
CUT&RUN (1)

Release Date

2025 (92)
2015 (91)
2023 (77)
2013 (63)
2016 (63)
2014 (62)
2021 (59)
2024 (56)
2018 (56)
2012 (55)
2022 (53)
2019 (53)
2011 (49)
2010 (47)
2020 (47)
2017 (38)
2008 (35)
2009 (31)
2026 (21)
2007 (19)
2006 (17)
2001 (9)
2005 (8)
2004 (8)
2003 (7)
2002 (5)
2000 (4)
1997 (3)
1999 (2)
1998 (2)

Lab affiliation

University of Edinburgh (2)
Head of the Curie Institute Mass Spectrometry Platform (2)
Institut Curie (1)
Dr Fede Pelisch Principal Investigator Molecular Cell and Developmental Biology School of Life Sciences University of Dundee Dundee UK (1)
Institut Curie, PSL Research University, CNRS, UMR 144, 26 rue d’Ulm, F-75005, Paris, France. (1)
Technischen Universität Berlin wellcome trust centre for cell biology, University of Edinburgh (1)
MIT Department of Biology, Cambridge, MA, USA; Whitehead Institute for Biomedical Research, Cambridge, MA, USA. (1)
Wellcome Centre for Cell Biology, University of Edinburgh Institute of Biotechnology, Technische Universität Berlin (1)
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Uppsalalaan 8, 3584CT, Utrecht, the Netherlands. (1)
State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China (1)
University of Trento - Chromosome Segregation Lab - CIBIO (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands (1)
Ludwig-Maximilians-Universität München Protein Analysis Unit Molecular Biology Department Großhadernerstr. 9 82152 Planegg-Martinsried (1)
University of Trento (1)
National Center of Biomedical Analysis (1)
Max-Planck Institute for Molecular Physiology, Dortmund, Germany (1)
Institut Curie, CNRS, UMR 144, 26 rue dÃ¢â‚¬â„¢Ulm, 75005 Paris, France (1)
Chemical Cell Biology Leiden Univerity Medical Center Einthovenweg 20 2333ZC Leiden, The Netherlands (1)
Molecular Genetics, RPTU Kaiserslautern (1)
Michael Swann Building Max Born Crescent The University of Edinburgh Edinburgh EH9 3BF (1)
Institute of Parasitology, Biology Center, Czech Academy of Sciences, Branišovská 31, 370 05 České Budějovice, CZECH REPUBLIC (1)
MRC - Laboratory of Molecular Biology (1)
Room 4.17 Michael Swann Building The University of Edinburgh Max Born Crescent Edinburgh EH9 3BF (1)
Wellcome Centre for Cell Biology, University of Edinburgh (1)
Proteomics program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark (1)
Laboratoire de Spectrométrie de Masse Protéomique (LSMP) Institut Curie (1)
Ist. G. Gaslini (1)

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Telomeric repeats facilitate CENP-A incorporation via telomere binding proteins

The histone H3 variant, CENP-ACnp1, is normally assembled upon canonical centromeric sequences, but there is no apparent obligate coupling of sequence and assembly, suggesting that centromere location can be epigenetically determined. To explore the tolerances and constraints on CENP-ACnp1 depositio...

ORGANISM(S): Schizosaccharomyces pombe

2013-08-22 | E-GEOD-46427 | biostudies-arrayexpress

Single-cell RNA-Seq to study the effects of acute and chronic CENP-A overexpression depending on p53 status

We performed single-cell RNA-Seq to determine the effects of CENP-A overexpression and p53 status on cell fate over time. We established clonal MCF10-2A TetOn-CENPA-FLAG-HA cell lines where CENP-A can be reversibly induced by Doxycycline (Dox) treatment. We compared prolonged, continuous CENP-A over...

ORGANISM(S): Homo sapiens

2021-03-01 | E-MTAB-9861 | biostudies-arrayexpress

The N-terminal Tail of CENP-A Confers Epigenetic Stability to Centromeres via the CENP-T Branch of the CCAN in Fission Yeast

We employ the well-studied fission yeast centromere to investigate the function of the CENP-A (Cnp1) N-tail. We show that alteration of the N-tail did not affect Cnp1 loading at centromeres, outer kinetochore formation, or spindle checkpoint signaling, but nevertheless elevated chromosome loss. N-Ta...

ORGANISM(S): Schizosaccharomyces pombe

2015-04-16 | E-GEOD-63350 | biostudies-arrayexpress

CENP-A (Cnp1)

ChIP-seq of CENP-A in S. pombe

ORGANISM(S): Schizosaccharomyces pombe

2013-01-04 | E-MTAB-1435 | biostudies-arrayexpress

CENP-A ChIP-seq of MCF10-2A cells to study CENP-A localization following reversal from high to basal CENP-A expression

CENP-A, the centromeric histone H3 variant, is essential for the proper segregation of human chromosomes to daughter cells. High CENP-A expression leads to the misincorporation of CENP-A in non-centromeric chromatin and can promote an epithelial-mesenchymal transition (EMT). Here, we explored how C...

ORGANISM(S): Homo sapiens

2026-04-24 | E-MTAB-16636 | biostudies-arrayexpress

Factors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast

Specialized chromatin containing CENP-A nucleosomes instead of H3 nucleosomes is found at all centromeres. However, the mechanisms that specify the locations at which CENP-A chromatin is assembled remain elusive in organisms with regional, epigenetically regulated centromeres. It is known that norma...

ORGANISM(S): Schizosaccharomyces pombe

2015-02-19 | E-GEOD-66106 | biostudies-arrayexpress

Genome-wide maps of WT and over-expressing CenH3/CENP-A in Human HeLa S3 cells

Centromeres are essential to ensure proper chromosome segregation in eukaryotes. Their definition relies on the presence of a centromere-specific H3 histone variant CenH3, known as CENP-A in mammals. Its overexpression in aggressive cancers raises questions concerning its effect on chromatin dynamic...

ORGANISM(S): Homo sapiens

2014-02-12 | E-GEOD-42951 | biostudies-arrayexpress

Bulk RNA-Seq to study the effects of CENP-A overexpression, p53 status, and X- irradiation treatment in MCF-10-2A cells

We performed bulk RNA-Seq to investigate global transcriptional changes upon overexpression of the centromeric H3 variant CenH3/CENP-A in p53 wild-type and defective cells, and after X-irradiation treatment. We established clonal MCF-10-2A TetOn-CENPA-FLAG-HA cell lines where CENP-A can be reversibl...

ORGANISM(S): Homo sapiens

2021-03-01 | E-MTAB-9867 | biostudies-arrayexpress

CENP-A and H3.3 ChIP-seq of MCF10-2A cells to study how high CENP-A levels promote EMT

ORGANISM(S): Homo sapiens

2026-04-24 | E-MTAB-15579 | biostudies-arrayexpress

Mediator promotes CENP-A incorporation at fission yeast centromeres

This SuperSeries is composed of the following subset Series: GSE32310: Transcriptome analysis of mediator Med20 mutant and dcr1 mutant in S.pombe GSE35524: Mediator promotes CENP-A incorporation at fission yeast centromeres [ChIP-seq] Refer to individual Series

ORGANISM(S): Schizosaccharomyces pombe

2012-11-06 | E-GEOD-35527 | biostudies-arrayexpress

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1627 Results

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