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ProteomicsSkeletal Muscle TFEB Signaling Promotes Central Nervous System Function and Reduces Neuroinflammation during Aging and Neurodegenerative Disease
Skeletal muscle has recently arisen as a novel regulator of Central Nervous System (CNS) function and aging, secreting bioactive molecules known as myokines with metabolism-modifying functions in targeted tissues, including the CNS. Here we report the generation of a novel transgenic mouse with enha...
ORGANISM(S): Mus Musculus 
2023-12-06 | PXD045241 | panorama
TranscriptomicscaArray_golub-00460: Prediction of central nervous system embryonal tumour outcome based on gene expression
Embryonal tumours of the central nervous system (CNS) represent a heterogeneous group of tumours about which little is known biologically, and whose diagnosis, on the basis of morphologic appearance alone, is controversial. Medulloblastomas, for example, are the most common malignant brain tumour of...
ORGANISM(S): Homo sapiens 
2015-05-16 | E-GEOD-68956 | biostudies-arrayexpress
TranscriptomicsIdentification of central nervous system genes involved in the host response to the scrapie agent.
In this study we identified genes differentially expressed in the central nervous system (CNS) of mice during infection with mouse-adapted scrapie agents. We used cDNA microarrays to examine gene expression profiles at early, mid (pre-clinical) and late (clinical) time points after inoculation. Keyw...
ORGANISM(S): Mus musculus 
2004-10-13 | E-GEOD-1840 | biostudies-arrayexpress
ProteomicsPhosphoproteome Analysis of Cerebrospinal Fluid Extracellular Vesicles in Primary Central Nervous System Lymphoma
Primary central nervous system lymphoma(PCNSL) is a rare extra-nodal non-Hodgkin’s lymphoma and accounts for 3%-4% of central nervous system tumors. Recent studies have highlighted the importance of cerebrospinal fluid derived extracellular vesicles in PCNSL. Extracellular vesicles(EVs) are nanoscal...
ORGANISM(S): Homo Sapiens (human) 
2023-07-12 | PXD040744 | JPOST Repository
TranscriptomicsRNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease
Expression profiling of distinct central nervous system (CNS) cell populations has been employed to facilitate disease classification and to provide insights into the molecular basis of brain pathology. One important cell type implicated in a wide variety of CNS disease states is the resident brain ...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-53789 | biostudies-arrayexpress
TranscriptomicsGenomic aberrations in primary central nervous system lymphoma (PCNSL)
Genomic aberrations in primary central nervous system lymphoma (PCNSL). Two-condition experiment, PCNSLs vs. healthy men. Biological replicates: 12 tumors replicates, 13 peripheral blood replicates.
ORGANISM(S): Homo sapiens 
2010-11-13 | E-GEOD-25298 | biostudies-arrayexpress
TranscriptomicsMCMV Infection of Developing Central Nervous System, Developmental and Immunological Response
Prenatal Human Cytomegalovirus (HCMV) infection often causes CNS maldevelopment. In a murine model, we detect Murine Cytomegalovirus (MCMV) in brain following intra-peritoneal inoculation at birth. Infected mice show impaired cerebellar development and impaired neurologic function on a beam balance...
ORGANISM(S): Mus musculus 
2008-05-31 | E-GEOD-9945 | biostudies-arrayexpress
TranscriptomicsGenomic profiling combined with gene expression profiling in primary central nervous system lymphoma
This SuperSeries is composed of the following subset Series: GSE25297: Genome-wide gene expression comparison (primary central nervous system lymphoma (PCNSL) vs normal lymph node) GSE25298: Genomic aberrations in primary central nervous system lymphoma (PCNSL) Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-11-13 | E-GEOD-25299 | biostudies-arrayexpress
GenomicsThe mutational landscape of primary central nervous system lymphoma (Hipo H050, A050, XD013)
Primary lymphomas of the central nervous system (PCNSL) are diffuse large B-cell lymphomas (DLBCLs) which are confined to the central nervous system (CNS). Despite extensive research, the molecular alterations leading to PCNSL have not been fully elucidated. In order to provide a comprehensive descr...
EGAS00001005339 | EGA
TranscriptomicsRNA-seq analysis of single cells of the oligodendrocyte lineage from nine distinct regions of the anterior-posterior and dorsal-ventral axis of the mouse juvenile central nervous system
5069 transcriptomes of single oligodendrocyte cells from spinal cord, substantia nigra-ventral tegmental area, striatum, amygdala, hypothalamic nuclei, zona incerta, hippocampus, and somatosensory cortex of male and female mice between post-natal day 21 and 90. The study aimed at identifying diverse...
ORGANISM(S): Mus musculus 
2016-06-10 | E-GEOD-75330 | biostudies-arrayexpress
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