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TranscriptomicsIdentification of central nervous system genes involved in the host response to the scrapie agent.
In this study we identified genes differentially expressed in the central nervous system (CNS) of mice during infection with mouse-adapted scrapie agents. We used cDNA microarrays to examine gene expression profiles at early, mid (pre-clinical) and late (clinical) time points after inoculation. Keyw...
ORGANISM(S): Mus musculus 
2004-10-13 | E-GEOD-1840 | biostudies-arrayexpress
TranscriptomicsMCMV Infection of Developing Central Nervous System, Developmental and Immunological Response
Prenatal Human Cytomegalovirus (HCMV) infection often causes CNS maldevelopment. In a murine model, we detect Murine Cytomegalovirus (MCMV) in brain following intra-peritoneal inoculation at birth. Infected mice show impaired cerebellar development and impaired neurologic function on a beam balance...
ORGANISM(S): Mus musculus 
2008-05-31 | E-GEOD-9945 | biostudies-arrayexpress
MetabolomicsGlobal Metabolomic Profiling of Mice Brains following Experimental Infection with the Cyst-Forming Toxoplasma gondii
The interplay between the Apicomplexan parasite Toxoplasma gondii and its host has been largely studied. However, molecular changes at the metabolic level in the host central nervous system and pathogenesis-associated metabolites during brain infection are largely unexplored. We used a global metabo...
2017-01-27 | MTBLS217 | MetaboLights
TranscriptomicsFunctional genomics of central nervous system and liver following herpes simplex virus corneal infection.
The overall goal of the study was to use in vivo data combined with functional genomics to define gene expression signatures representative of a spectrum of HSV CNS infections. Innate immune deficiencies result in a spectrum of severe clinical outcomes following infection. In particular, there is a ...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-35943 | biostudies-arrayexpress
ProteomicsEchovirus-30 Infection Alters Host Proteins in Lipid Rafts at the Cerebrospinal Fluid Barrier In Vitro
Echovirus-30 (E-30) is a non-polio enterovirus responsible for meningitis outbreaks in children worldwide. To gain access to the central nervous system (CNS), E-30 first has to cross the blood-brain barrier (BBB) or the blood-cerebrospinal fluid barrier (BCSFB). E-30 may use lipid rafts of the host ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-12-29 | MSV000086646 | MassIVE
TranscriptomicsTranscription profiling of brain from mice with multiple sclerosis, Alzheimers disease and permanent mid-cerebral artery occlusion from stroke to compare of gene expression changes characterizing these three different central nervous system pathologies
Three mouse models of human central nervous system pathologies were selected for analyzing gene expression changes compared to wild type normal brain. The selected models are: TgAPP23 for Alzheimerï¾’s disease (see Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.H., Mistl, C., Rothac...
ORGANISM(S): Mus musculus 
2008-07-12 | E-MTAB-1 | biostudies-arrayexpress
TranscriptomicsGenes induced after BDV infection in Sprague Dawley and Lewis rats
Borna Disease Virus (BDV) is a neurotropic virus that persistently infects neurons in the central nervous system of various hosts, including rats. Although BDV is known to be an IFN sensitive virus, determination of the cellular mRNA transcript levels revealed the induction of IFN-stimulated genes i...
ORGANISM(S): Rattus norvegicus 
2013-06-26 | E-GEOD-41540 | biostudies-arrayexpress
ProteomicsBacteria Commonly Associated with Central Nervous System Catheter Infections Elicit Distinct CSF Proteome Signatures
Cerebrospinal fluid (CSF) shunt infection is a common and devastating complication of the treatment of hydrocephalus. Timely and accurate diagnosis is essential as these infections can lead to long term neurologic consequences like seizures, decreased IQ and impaired school performance. Currently th...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-01-30 | PXD038238 | Pride
Inflammation P. aeruginosa Central nervous system infection Cns Csf Infection Shunt infection Proteome S. epidermidis Biomarker C. acnes 
TranscriptomicsTranscription profiling of rhesus monkeys through HIV disease progression and impact on neuroAIDS.
The virus/host interactions during the acute phase of human immunodeficiency virus (HIV) infection help determine the course of disease. During this time period, virus enters the brain. Here, we report clusters of genes whose transcripts are significantly upregulated in the frontal lobe of the brain...
ORGANISM(S): Macaca mulatta 
2008-06-12 | E-GEOD-2393 | biostudies-arrayexpress
GenomicsSystems analysis of viral infection in the embryonic central nervous system (CNS)
Systems analysis of viral infection in the embryonic central nervous system (CNS)
PRJNA487357 | ENA
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