Centromeres - OmicsDI

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UNIPROT ID/AC

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CHEBI ID

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Metabolite Name

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Modelling Approach

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Lab affiliation

Vetsuisse Faculty (VET), Department of Molecular Mechanisms of Disease, University of Zurich (UZH) (3)
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King Abdullah University of Science & Technology (KAUST), Biological Environmental Sciences and Engineering Division BESE, KAUST Environmental Epigenetics Program, Thuwal, Saudi Arabia. (1)
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Chromatin Proteomics Biomedical Center, LMU München Grosshaderner Strasse 9 D-82152 Planegg-Martinsried +4989218075420 (1)
Pku-iaas, Shandong,China (1)
Chromosome Dynamics and Stability Group, Genome Damage and Stability Centre, University of Sussex, Brighton, BN1 9RQ, United Kingdom (1)
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Institut Curie, CNRS, UMR 144, 26 rue dÃ¢â‚¬â„¢Ulm, 75005 Paris, France (1)
Michael Swann Building Max Born Crescent The University of Edinburgh Edinburgh EH9 3BF (1)
Department of Radiation Oncology Dana-Farber Cancer Institute USA (1)
Max Perutz Labs Dept. Chromosome Biology University of Vienna (1)
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Classification

protozoa (14)
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bacteria (2)

Study type

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Holocentromeres are dispersed point centromeres localized at transcription factor hotspots

The centromere is a defining feature of eukaryotic chromosomes and is essential for the segregation of chromosomes during cell division. Centromeres are universally marked by the histone variant cenH3 and are restricted to specialized chromatin that most commonly localized to a single position along...

ORGANISM(S): Caenorhabditis elegans

2014-04-08 | E-GEOD-44412 | biostudies-arrayexpress

Mediator promotes CENP-A incorporation at fission yeast centromeres

This SuperSeries is composed of the following subset Series: GSE32310: Transcriptome analysis of mediator Med20 mutant and dcr1 mutant in S.pombe GSE35524: Mediator promotes CENP-A incorporation at fission yeast centromeres [ChIP-seq] Refer to individual Series

ORGANISM(S): Schizosaccharomyces pombe

2012-11-06 | E-GEOD-35527 | biostudies-arrayexpress

Genome-wide mapping of cytosine methylation revealed dynamic DNA methylation patterns associated with rice centromeres

Specification and propagation of the centromeres of eukaryotic chromosomes is determined by epigenetic mechanisms. Unfortunately, the epigenetic characteristics of centromeric DNA and chromatin are difficult to define because the centromeres are composed of highly repetitive DNA sequences in most eu...

ORGANISM(S): Oryza sativa

2010-04-22 | E-GEOD-21414 | biostudies-arrayexpress

Mediator promotes CENP-A incorporation at fission yeast centromeres [ChIP-seq]

At Schizosaccharomyces pombe centromeres, heterochromatin formation is required for de novo incorporation of the histone H3 variant CENP-A/Cnp1, which in turn directs kinetochore assembly and ultimately chromosome segregation during mitosis. Noncoding RNAs (ncRNAs) transcribed by RNA polymerase II (...

ORGANISM(S): Schizosaccharomyces pombe

2012-11-06 | E-GEOD-35524 | biostudies-arrayexpress

The N-terminal Tail of CENP-A Confers Epigenetic Stability to Centromeres via the CENP-T Branch of the CCAN in Fission Yeast

We employ the well-studied fission yeast centromere to investigate the function of the CENP-A (Cnp1) N-tail. We show that alteration of the N-tail did not affect Cnp1 loading at centromeres, outer kinetochore formation, or spindle checkpoint signaling, but nevertheless elevated chromosome loss. N-Ta...

ORGANISM(S): Schizosaccharomyces pombe

2015-04-16 | E-GEOD-63350 | biostudies-arrayexpress

Nucleosome Mapping in S. pombe Centromeres

A key element for defining the centromere identity is the incorporation of a specific histone H3, CENP-A, known as Cnp1p in S. pombe. Previous studies have suggested that functional S. pombe centromeres lack nucleosome arrays and may involve chromatin remodeling as a key step of kinetochore assembl...

ORGANISM(S): Schizosaccharomyces pombe

2008-05-30 | E-GEOD-10742 | biostudies-arrayexpress

Centromere-Like Regions in Budding Yeast

Accurate chromosome segregation requires centromeres (CENs), the chromosomal sites where kinetochores form, to bridge DNA and attach to microtubules. In contrast to most eukaryotes, Saccharomyces cerevisiae possesses sequence-defined point centromeres. Chromatin immunoprecipitation followed by seq...

ORGANISM(S): Saccharomyces cerevisiae

2013-01-18 | E-GEOD-31466 | biostudies-arrayexpress

Euchromatic histone modifications associated with rice centromeres

The centromere is defined by the presence of a centromere-specific histone H3 variant, CENH3. Establishment and maintenance of the centromeric chromatin (CEN chromatin) is determined by poorly understood epigenetic mechanisms. Interestingly, CEN chromatin in several eukaryotes showed euchromatic c...

ORGANISM(S): Oryza sativa

2011-11-09 | E-GEOD-29597 | biostudies-arrayexpress

The CentO satellite confers translational and rotational phasing on cenH3 nucleosomes in rice centromeres

Plant and animal centromeres comprise megabases of highly repeated satellite sequences, yet centromere function can be specified epigenetically on single-copy DNA by the presence of nucleosomes containing a centromere-specific variant of histone H3 (cenH3). We determined the positions of cenH3 nucle...

ORGANISM(S): Oryza sativa

2013-11-06 | E-GEOD-50755 | biostudies-arrayexpress

A transcriptional roadblock protects yeast centromeres

PRJNA781283 | ENA

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