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TranscriptomicsCentrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals
Centrosome amplification is a common feature of human tumors, but whether this is a cause or a consequence of human cancer remains unclear. Here, we report the creation of a mouse model in which centrosome number can be persistently increased in the absence of additional genetic defects. We show tha...
ORGANISM(S): Mus musculus 
2017-02-04 | E-MTAB-5043 | biostudies-arrayexpress
ProteomicsSILAC analysis of exosome secretion in response to centrosome amplification
We performed quantitative proteomics analysis by Stable Isotope Labelling by Amino Acids in Cell culture (SILAC) to understand how centrosome amplification changes the composition of human small extracellular vesicles. We carried out SILAC labelling with medium and heavy isotopes, as it enables the ...
ORGANISM(S): Homo sapiens (Human) 
2021-01-19 | PXD020984 | Pride
Exosomes Small extracellular vesicles. Centrosome amplification Silac 
ProteomicsPCNA and JNK1-Stat3 pathways respectively promotes and inhibits centrosome amplification by targeting at the ROCK1/14-3-3σ complex
We have recently reported that type 2 diabetes promotes cell centrosome amplification via enhancing the expression, biding and centrosome translocation of ROCK1/14-3-3σ complex. In the present functional proteomic study, we further investigated the molecular pathways underlying the centrosome amplif...
ORGANISM(S): Homo Sapiens 
2018-03-30 | PXD009370 |
GenomicsCentrosome amplification triggers tumorigenesis in p53 deficient epidermis
While aneuploidy is found in more than 90% of solid tumors, it is unclear whether aneuploidy is the cause or the consequence of tumorigenesis. Different mouse models deficient in centrosomal or spindle checkpoint proteins that induce aneuploidy show either a promotion or a decrease in tumorigenesis ...
ORGANISM(S): Mus musculus 
2015-10-27 | E-MTAB-3733 | biostudies-arrayexpress
GenomicsRNA-seq of cells with centrosome amplification
RNA-seq of cells with centrosome amplification
PRJEB48608 | ENA
GenomicsCentrosome amplification triggers tumorigenesis in p53 deficient epidermis
Centrosome amplification triggers tumorigenesis in p53 deficient epidermis
PRJEB9840 | ENA
GenomicsCentrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals
Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals
PRJEB15173 | ENA
TranscriptomicsGene expression in mitotic tissues of Drosophila larvae without centrosomes or too many centrosomes
Centrosome defects are a common feature of many cancers. Surprisingly, flies can proceed through the majority of development without centrosomes or with amplified centrosomes in most of their cells. It is unclear whether this is because centrosome defects do not cause many problems in Drosophila cel...
ORGANISM(S): Drosophila melanogaster 
2012-08-20 | E-GEOD-35240 | biostudies-arrayexpress
GenomicsOncogene-like induction of cellular invasion from centrosome amplification
Centrosome amplification has long been recognized as a feature of human tumors, however its role in tumorigenesis remains unclear. Centrosome amplification is poorly tolerated by non-transformed cells, and, in the absence of selection, extra centrosomes are spontaneously lost. Thus, the high frequen...
ORGANISM(S): Homo sapiens 
2014-03-01 | GSE55042 | GEO
GenomicsCEP120 Promotes Centrosome Amplification And Progression Of Gastric Cancer Via USP54-Mediated Deubiquitination Of PLK4
CEP120 Promotes Centrosome Amplification And Progression Of Gastric Cancer Via USP54-Mediated Deubiquitination Of PLK4
PRJNA899551 | ENA
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