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TranscriptomicsINK4A expression in leukemic cells transformed by the v-Myb oncoprotein depends on the integrity of the v-Myb leucine zipper region
The AMV v-Myb oncoprotein causes oncogenic transformation of myelomonocytic cells in vivo and in vitro. Its transforming capacity is strictly dependent upon the N-terminal DNA binding domain, the central transactivation region, and on the C-terminal domain containing a putative leucine zipper motif....
ORGANISM(S): Gallus gallus 
2012-04-11 | E-GEOD-35413 | biostudies-arrayexpress
TranscriptomicsEGR1 regulates metastatic potential of v-src transformed chicken sarcoma cell lines
A model of tumor metastasis based on v-src transformed immortalized cell lines was developed. The model consists of highly metastatic PR9692 cell line and a derived clone PR9692-E9 which has lost the metastatic abilities. Introduction of exogenous EGR1 gene into the non-metastasizing PR9692-E9 cells...
ORGANISM(S): Gallus gallus 
2010-04-06 | E-GEOD-15141 | biostudies-arrayexpress
ProteomicsCRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation
HEK293T cells were co-transfected with StrepII-FLAG-tagged DCAF12 and HA-tagged CUL4A, grown for 48 h, harvested, and lysed as described above. In the first step, Strep-TactinXT Superflow resin (IBA Lifesciences, Gottingen, Germany) was used to purify proteins associated with StrepII-FLAG-tagged sub...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-04-01 | MSV000097470 | MassIVE
TranscriptomicsThe oncoprotein v-Myb activates transcription of Gremlin 2 during differentiation of the chicken neural crest to melanoblasts
The neural crest (NC) is a transient dynamic structure of ectodermal origin, found in early vertebrate embryos. The multipotential NC cells migrate along well defined routes, differentiate to various cells types including melanocytes and participate in the formation of various permanent tissues. Abn...
ORGANISM(S): Gallus gallus 
2012-07-13 | E-GEOD-39346 | biostudies-arrayexpress
TranscriptomicsConstitutive expression of EGR4 elicits cell cycle shortening in primary mesenchymal cells.
Transcription factors of EGR family mediate cellular responses to MAPK signaling. Albeit working in parallel to proliferation associated AP-1 factors their involvement in cell cycle regulation has not been demonstrated so far. This work reveals pronounced cell cycle shortening following constitutive...
ORGANISM(S): Gallus gallus 
2010-04-06 | E-GEOD-15143 | biostudies-arrayexpress
TranscriptomicsDownregulation of the HOPX gene decreases metastatic activity in a chicken sarcoma cell line model and identifies genes associated with metastasis
Metastatic progression is the leading cause of cancer mortality yet we have an incomplete view of the genetic events governing this process. An investigation was undertaken to explore the role of homeodemain only protein X (HOPX) in metastatic propensity and to identify other genes that may particip...
ORGANISM(S): Gallus gallus 
2012-11-27 | E-GEOD-42516 | biostudies-arrayexpress
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