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MetabolomicsDirect on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights
MetabolomicsDistinct Cervical Microbiome and Metabolite Profiles Before and After Menopause: Implications for Cervical Cancer Progression

Introduction: Cervical cancer is the fourth most common malignancy in women and is primarily caused by persistent infection with high-risk human papillomavirus (HPV). In addition, host immune responses, genetic factors, and lifestyle habits also have etiological roles. The cervicovaginal microbio...

2025-07-07 | MTBLS12691 | MetaboLights
MetabolomicsInteraction between Cervical Microbiota and Host Gene Regulation in Caesarean Section Scar Diverticulum

Cesarean section scar diverticulum (CSD) has become a formidable obstacle preventing women receiving CS from reproducing. However, the pathogenesis of CSD remains unexplored. In this study, we characterized the cervical microbiota, metabolome and endometrial transcriptome of women with CSD. Based...

2022-07-25 | MTBLS4967 | MetaboLights
Proteomics: Pap test, cervical swab, and tumor tissue LC-MS/MS proteomics from a case of high grade serous ovarian cancer.
The aim of this study was to determine whether the residual fixative from a liquid-based Pap test or a swab of the cervix contained proteins that were also found in the primary tumor of a woman with high grade serous ovarian cancer. A total of 4,934 proteins were identified and analyzed. This study...
ORGANISM(S): Homo sapiens (Human) 
2021-01-12 | PXD023272 | Pride
Pap test Ovarian cancer Tumor tissue Cervical swab Biomarkers 
MetabolomicsMulti-omic analysis of vaginal bacteria:host immune and metabolic interactions in early adverse pregnancy outcomes

Objective

To characterise the vaginal microbiota, mucosal metabolome and host immune response in early pregnancy and investigate its relationship with adverse pregnancy outcomes, including ectopic pregnancy, within the context of pregnancies of unknown location (PUL).

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2025-03-28 | MTBLS10098 | MetaboLights
TranscriptomicsTMEM45A, SERPINB5 and p16INK4A transcript levels are predictive for development of high-grade cervical lesions
Women persistently infected with human papillomavirus (HPV) type 16 are at high risk for development of cervical intraepithelial neoplasia grade 3 or cervical cancer (CIN3+). We aimed to identify biomarkers for progression to CIN3+ in women with persistent HPV16 infection. In this prospective study,...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-75132 | biostudies-arrayexpress
GenomicsHuman papillomavirus strain:genus
Alpha-HPV-targeted sequence for cervical swab specimens
PRJDB15907 | ENA
UnknownComparison of human papillomavirus (HPV) detection in urine and cervical swab samples using the HPV GenoArray Diagnostic assay.
Not available
S-EPMC5637711 | biostudies-literature
UnknownComplete Genome Sequence of a Novel Human Gammapapillomavirus Isolated from a Cervical Swab in Luxembourg.
Not available
S-EPMC5854775 | biostudies-literature
UnknownViability of Self-Taken Vaginal Swab Samples for RNA-Based Biomarker Analysis in Cervical Disease.
Not available
S-EPMC12683698 | biostudies-literature
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