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TranscriptomicsOvercoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins
Unraveling the underlying mechanisms of cetuximab resistance in head and neck squamous cell carcinoma (HNSCC) is of major importance as many tumors remain non-responsive or become resistant. Out microarray results suggest that resistant cells still exhibit RAS-MAPK pathway signaling contributing to ...
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-61495 | biostudies-arrayexpress
TranscriptomicsRegulation of HB-EGF by miR-212 and acquired cetuximab-resistance in head and neck cancer
To determine the mechanism of cetuximab-resistance in head and neck cancer, a cetuximab-sensitive cell line (SCC1) and its cetuximab-resistant derivative (1Cc8) were analyzed for differentially expressed genes using DNA microarrays. 900 differentially expressed genes were found using the statistical...
ORGANISM(S): Homo sapiens 
2011-01-14 | E-GEOD-21483 | biostudies-arrayexpress
TranscriptomicsGenomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients
Anti-EGFR antibodies are effective in therapies for late-stage colorectal cancer (CRC); however, many tumours are unresponsive or develop resistance. We performed genomic analysis of intrinsic and acquired resistance to anti-EGFR therapy in prospectively collected tumour samples from 25 CRC patients...
ORGANISM(S): Homo sapiens 
2019-09-21 | E-MTAB-8340 | biostudies-arrayexpress
TranscriptomicsActivation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab
HCC827 cells were grown in gradually increasing concentrations of cetuximab beginning at 0.1 ug/ml. Drug concentrations were slowly increased until the resistant cells were able to proliferate in 100 ug/ml of cetuximab. Individual clones of cetuximab resistant (CR; CR1 to CR4) cells were isolated an...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-30255 | biostudies-arrayexpress
ProteomicsProteomics uncover EPHA2 in cetuximab resistant colorectal cancer cell lines as a potential novel therapeutic target
In metastatic colorectal cancer (mCRC), primary and acquired resistance against anti-EGFR targeted monoclonal antibodies, such as cetuximab (CET), were shown to be frequently caused by activating alterations in RAS genes (KRAS or NRAS). To this day no efficient second-line treatment options have eme...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD022072 | Pride
Epha2 Cetuximab resistance Proteomics 
TranscriptomicsGene expression signatures modulated by epidermal growth factor receptor activation and their relationship to cetuximab resistance in head and neck squamous cell carcinoma
Aberrant activation of signaling pathways controlled in normal epithelial cells by the epidermal growth factor receptor (EGFR) has been linked to cetuximab (a monoclonal antibody against EGFR) resistance in head and neck squamous cell carcinoma (HNSCC). To infer relevant and specific pathway activat...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-32975 | biostudies-arrayexpress
ModelsPark2019 - Cetuximab resistance in colorectal cancer
It's an experimental + mathematical paper explaining probable targets for Cetixumab resistance in colorectal cancer.
2019-09-30 | MODEL1909300004 | BioModels
Oncology 
TranscriptomicsCetuximab resistant or sensitive head and neck cancer samples
10 cell lines (five cetuximab sensitive and five cetuximab resistant) were selected for gene copy number array analysis on the Affymetrix SNP 6.0 platform. 39 protein coding genes were amplified in cetuximab resistant cells and normal in sensitive cells, all present on genomic regions 11q22.1 or 5p1...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-36790 | biostudies-arrayexpress
TranscriptomicsInsulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma
Recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains one of the most difficult cancers to treat with limited chemotherapeutic options. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents; c...
ORGANISM(S): Homo sapiens 
2010-08-03 | E-GEOD-9600 | biostudies-arrayexpress
GenomicsMolecular mechanisms and potential therapeutic drugs linking to cetuximab-resistance reactions in cancer cells
Molecular mechanisms and potential therapeutic drugs linking to cetuximab-resistance reactions in cancer cells
PRJNA473145 | ENA
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