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TranscriptomicsColonic gene expression data of TIMP1 knock out colitis mice
Increased levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) have been detected in fibrotic strictures in Crohn’s disease. In a murine model of chronic inflammation, fibrosis was associated with an increase in TIMP-1 and inhibition of matrix metalloproteinase (MMP)-mediated degradation. We...
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-73424 | biostudies-arrayexpress
TranscriptomicsColonic gene expression data of acute and chronic dextran sodium sulphate (DSS) colitis mice
The lack of suitable animal models reflecting chronically relapsing inflammation and tissue remodeling have hindered fibrosis research in inflammatory bowel diseases (IBD). This study investigated changes in connective tissue in a chronic murine model using different cycles of dextran sodium sulphat...
ORGANISM(S): Mus musculus 
2013-09-03 | E-GEOD-42768 | biostudies-arrayexpress
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