Sort   by:  
 Page size 
TranscriptomicsGene expression in CF-vs-non CF human airway epithelial cell samples obtained by nasal brushing.
A small-scale whole genome microarray study of gene expression in human native nasal epithelial cells from F508del-CFTR homozygous CF patients and non-CF controls. We used the custom designed Affymetrix HsAirwaya520108F Arrays to compare gene expression in 5 CF and 5 non CF nasal epithelial cell sam...
ORGANISM(S): Homo sapiens 
2013-04-10 | E-GEOD-40445 | biostudies-arrayexpress
TranscriptomicsGene expression in rectal epithelia of cystic fibrosis patients
Gene expression profiles were recorded from rectal suction specimens of Cystic Fibrosis (CF) patients, carrying the CF-specific D508 mutated CFTR-allele. These profiles were compared with gene expression profiles from rectal suction specimens of non-CF subjects (control). We used Affymetrix GeneChi...
ORGANISM(S): Homo sapiens 
2013-11-28 | E-GEOD-15568 | biostudies-arrayexpress
TranscriptomicsPaneth cell granule dissolution and bacterial colonization in the intestine of CF mice
Paneth cells of intestinal crypts contribute to host defense by producing antimicrobial peptides that are packaged as granules for secretion into the crypt lumen. Here, we provide evidence using light and electron microscopy that postsecretory Paneth cell granules undergo limited dissolution and acc...
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-2958 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiling in Cystic Fibrosis Airway Epithelium
Cystic fibrosis (CF) is one of the commonest lethal genetic diseases in which the role of microRNAs (miRNAs) has yet to be explored. We hypothesized that unique miRNA expression profiles exist in CF versus non-CF bronchial epithelial cells so the our aim was to investigate whether unique miRNA expre...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-19431 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Pseuodomonas aeruginosa cystic fibrosis (CF) isolates
To provide a more detailed survey of adaptive changes in the physiology of P. aeruginosa (PA) during long-term infection of the cystic fibrosis (CF) lung, we performed a comparative proteome and transcriptome analysis of a set of isogenic sequential non-mutator and mutator isolates from three select...
ORGANISM(S): Pseudomonas aeruginosa 
2009-06-08 | E-GEOD-10362 | biostudies-arrayexpress
TranscriptomicsAltered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice.
Cystic fibrosis (CF) mouse models exhibit exocrine pancreatic function yet do not develop adipose stores to the levels of non-CF mice. CF mice homozygous for the Cftr mutation (F508del) at 3 weeks (post-weaning) and 6 weeks (young adult) of age had markedly less adipose tissue than non-CF mice. Both...
ORGANISM(S): Mus musculus 
2012-06-17 | E-GEOD-33319 | biostudies-arrayexpress
TranscriptomicsRescue Of Dysfunctional Autophagy By Peptide IDR-1018 Attenuates Hyperinflammatory Phenotype Of Cystic Fibrosis Cells (RNA-seq)
Genome-wide gene expression was measured in peripheral blood mononuclear cells (PBMCs) from patients with cystic fibrosis (CF) after treatment in vitro with the flagellin protein fliC, and/or synthetic peptide IDR-1018 to assess patterns of gene expression. The patterns of gene expression suggest th...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-35394 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of nasal epithelium from CF patients with mild and severe cystic fibrosis lung disease to identify candidate genes that influence the severity of pulmonary disease and to identify genes indicative of CF disease progression
Summary: CF patients homozygous for the DF08 DF08 genotype present a full range of phenotypic manifestations that exist within the pulmonary system. This project aims to identify candidate genes that influence the severity of pulmonary disease; Hypothesis: The goal is to find genes predictive of pro...
ORGANISM(S): Homo sapiens 
2007-10-24 | E-GEOD-2395 | biostudies-arrayexpress
GenomicsBacteroidales bacterium CF strain:CF
A fermenting organism from CF metagenome
PRJNA218492 | ENA
GenomicsMethanococcus mangrovi strain:CF
Methanococcus mangrovi strain:CF Genome sequencing
PRJNA1298959 | ENA
Sort   by:  
 Page size