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TranscriptomicsTranscription profiling of mouse embryonic fibroblasts normoxia/hypoxia treatments with mutations in the CH1 domains of p300 and CBP
The CH1 (TAZ) domain of the transcriptional coactivators p300 and CBP has been reported to interact with the transcription factor HIF-1alpha and this interaction is thought to be critical for HIF-1alpha target gene expression in response to hypoxia. To determine the requirement for the CH1 domain i...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3195 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse CH1 B-cells upon stimulation either with anti-IgM, IL-4 or with a combination of anti-IgM and IL-4
We have studied CH1 cells that undergo G1 arrest upon anti-IgM treatment after 16 hrs of stimulation. First we studied the differential gene expression under anti-IgM and IL-4 stimulation condition individually and in combination, and this revealed the affected genes to be directly or indirectly pla...
ORGANISM(S): Mus musculus 
2010-01-19 | E-MTAB-82 | biostudies-arrayexpress
TranscriptomicsA Region of Human HoxD that Confers Polycomb-Group Responsiveness
Polycomb group (PcG) proteins are essential for accurate axial body patterning during embryonic development. PcG-mediated repression is conserved in metazoans and is targeted in Drosophila by Polycomb response elements (PREs). Targeting sequences in humans have not been described. While analyzing c...
ORGANISM(S): Homo sapiens 
2010-06-19 | E-GEOD-19046 | biostudies-arrayexpress
TranscriptomicsWidespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity
Transfected siRNAs and miRNAs regulate numerous transcripts that have only limited complementarity to the active strand of the RNA duplex. This process reflects natural target regulation by miRNAs, but is an unintended (â??off-targetâ??) consequence of siRNA-mediated silencing. Here we demonstrate...
ORGANISM(S): Homo sapiens 
2006-09-12 | E-GEOD-5814 | biostudies-arrayexpress
ProteomicsTyrosine phosphorylation site-specific interactome of adaptor protein Shc1 explored by synthetic protein domains
As a critical adaptor protein, Shc1 contains SH2 and PTB domains for scaffolding tyrosine phosphorylation-dependent protein complexes, therefore regulating growth factor receptor signaling networks. The three tyrosine phosphorylation sites (pY) on the CH1 linker region of SHC1 provide additional doc...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-08-15 | PXD049113 | Pride
Tyrosine phosphorylation Signal transduction Shc1 Mass spectrometry Ch1 region 
TranscriptomicsGene expression in Maize root region 1 at low water potential
Previous work showed that the maize primary root adapts to low water potential (-1.6 MPa) by maintaining longitudinal expansion in the apical 3 mm (region 1), whereas in the adjacent 4 mm (region 2) longitudinal expansion reaches a maximum in well-watered roots but is progressively inhibited at low ...
ORGANISM(S): Zea mays 
2010-05-26 | E-GEOD-9341 | biostudies-arrayexpress
TranscriptomicsAberrant heterochromatic foci are associated to deregulation of the GMCL1 gene in CH1 lymphoma B cells
Chromosome 1 pericentric heterochromatin rearrangements : potent drivers of nuclear architecture perturbations and gene deregulation in human B cell lymphoma Epigenetic perturbations are increasingly described in cancer cells where they are thought to contribute to deregulated gene expression and g...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20666 | biostudies-arrayexpress
TranscriptomicsExpression Analysis of Gastric Cancers
Microarray Expression profiles from 58 samples comprising of 3 normals and 55 gastric cancers is used for molecular subclassification of Gastric Cancers. Data Generation and Processing: The ratiometric data here is given by Ch1(Cy3)/Ch2(Cy5) where Ch2 is Universal Reference RNA from Stratagene. Two...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-2637 | biostudies-arrayexpress
UnknownImproving the CH1-CK heterodimerization and pharmacokinetics of 4Dm2m, a novel potent CD4-antibody fusion protein against HIV-1.
Not available
S-EPMC4966869 | biostudies-literature
TranscriptomicsNeuronal differentiation-associated gene profiling of the CHB50 cell line
To identify neuronal differentiation associated gene candidates We compared two, dual labeled, 9K mouse cDNA arrays, where one channel (Ch1) corresponds to the control (proliferation) condition and channel two corresponds to the treatment (differentiation) condition"
ORGANISM(S): Rattus norvegicus 
2006-11-30 | E-GEOD-5193 | biostudies-arrayexpress
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