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GenomicsRNA-seq of CH12F3 and Lig4-/- CH12F3 cells
RNA-seq of CH12F3 and Lig4-/- CH12F3 cells
PRJNA646268 | ENA
TranscriptomicsRNA-seq of CH12F3 and Lig4-/- CH12F3 cells
We perform RNA-seq in CH12F3 and Lig4-/- CH12F3 cells. The results show the deficiency of Lig4 triggers RIG-I-like receptor, NOD-like receptor, IL-17 signaling, Cytosolic DNA-sensing pathway, and Toll-like receptor signaling pathways. As these pathways play impotant roles in immune resposne, the RNA...
ORGANISM(S): Mus musculus 
2020-07-15 | GSE154443 | GEO
GenomicsMus musculus
CH12F3 UPDSeq
PRJNA1139184 | ENA
TranscriptomicsThe DSIF subunits Spt4 and Spt5 have several unexpected, distinct roles in regulating immunoglobulin class switch recombination
Class-switch recombination (CSR), induced by activation-induced cytidine deaminase, can be divided into two phases: DNA cleavage of the switch (S) regions, and the joining of the cleaved ends of the different S regions. Here, we show that the DSIF complex (Spt4 and Spt5), a transcription elongation ...
ORGANISM(S): Mus musculus 
2013-10-22 | E-GEOD-33206 | biostudies-arrayexpress
UnknownPHRF1 promotes the class switch recombination of IgA in CH12F3-2A cells.
Not available
S-EPMC10403053 | biostudies-literature
UnknownSplice variants of activation induced deaminase (AID) do not affect the efficiency of class switch recombination in murine CH12F3 cells.
Not available
S-EPMC4372541 | biostudies-literature
GenomicsEpigenetic changes by EZH2 inhibition increase translocations in B cells with high AID activity or DNA repair deficiency [LAM-HTGTS for CH12F3 cell]
Epigenetic changes by EZH2 inhibition increase translocations in B cells with high AID activity or DNA repair deficiency [LAM-HTGTS for CH12F3 cell]
PRJNA1106435 | ENA
TranscriptomicsAcetylated Histone Reader Brd4 functions as Repair Adaptor in Immunoglobulin Class Switch Recombination
Class Switch Recombination (CSR) is a B cell specific genomic alteration induced by activation induced cytidine deaminase (AID)-dependent DNA break, followed by repair and recombination at the immunoglobulin heavy-chain locus. The involvement of several chromatin-associated factors in promoting AID-...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-52239 | biostudies-arrayexpress
OtherEpigenetic changes by EZH2 inhibition increase translocations in B cells with high AID activity or DNA repair deficiency [LAM-HTGTS for CH12F3 cell]
The EZH2 histone methyltransferase inhibitors tazemetostat and valemetostat have recently received approval for clinical use in follicular lymphoma and adult T-cell leukemia/lymphoma, respectively. In follicular lymphoma, the expression of AID is responsible for increased mutational signatures and g...
ORGANISM(S): Mus musculus 
2025-11-18 | GSE266237 | GEO
TranscriptomicsThe histone chaperone Spt6 is required for AID target determination through H3K4me3 regulation
H3K4me3 plays a critical role in the activation-induced cytidine deaminase (AID)-induced DNA cleavage of switch (S) regions in the immunoglobulin heavy chain (IgH) locus during class-switch recombination (CSR). The histone chaperone complex facilitates chromatin transcription (FACT) is responsible f...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-35334 | biostudies-arrayexpress
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