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ProteomicsTargeting CHAF1B enhances interferon activity in myeloproliferative neoplasms
Interferons (IFNs) are cytokines with potent anti-neoplastic properties and significant clinical activity in the treatment of myeloproliferative neoplasms (MPNs). The use of pegylated IFN for the treatment of MPNs has been of particular interest, with several clinical trials establishing clinical r...
ORGANISM(S): Homo sapiens (Human) 
2023-05-15 | PXD037376 | Pride
Chaf1b Myeloproliferative neoplasms Interferon 
GenomicsA CHAF1B-dependent molecular switch in hematopoiesis and leukemia pathogenesis
A CHAF1B-dependent molecular switch in hematopoiesis and leukemia pathogenesis
PRJNA491485 | ENA
GenomicsTranscriptome analysis of CHAF1B depletion in Akata EBV+ Burkitt Lymphoma cells
Transcriptome analysis of CHAF1B depletion in Akata EBV+ Burkitt Lymphoma cells
PRJNA626463 | ENA
UnknownCHAF1B: the hidden culprit behind sorafenib resistance in hepatocellular carcinoma.
Not available
S-EPMC12492380 | biostudies-literature
TranscriptomicsA CHAF1B-dependent molecular switch in hematopoiesis and leukemia pathogenesis
CHAF1B is the p60 subunit of the chromatin assembly factor (CAF1) complex, which is responsible for assembly of H3.1/H4 heterodimers at the replication fork during S phase. Here we report that CHAF1B is required for normal hematopoiesis while its overexpression promotes leukemia. CHAF1B has a pro-le...
ORGANISM(S): Homo sapiens Mus musculus 
2018-11-12 | GSE120063 | GEO
UnknownTargeting CHAF1B Enhances IFN Activity against Myeloproliferative Neoplasm Cells.
Not available
S-EPMC10231401 | biostudies-literature
GenomicsRepression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development
Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development
PRJNA966178 | ENA
UnknownA CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis.
Not available
S-EPMC6235627 | biostudies-literature
UnknownUbiquitin ligase CHAF1B induces cisplatin resistance in lung adenocarcinoma by promoting NCOR2 degradation.
Not available
S-EPMC7249347 | biostudies-literature
TranscriptomicsTranscriptome analysis of CHAF1B depletion in Akata EBV+ Burkitt Lymphoma cells
RNAseq was used to identify host and EBV viral transcriptome changes in CHAF1B knock-out Akata EBV+ cells. CHAF1B KO Akata EBV+ cells were subjected to RNAseq analysis. The Akata EBV+ cells expressing control sgRNA was used as the control.
ORGANISM(S): Homo sapiens 
2020-10-15 | GSE148910 | GEO
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