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MetabolomicsDynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-related clear cell renal cancer cells (ccRCC) gro...

2022-12-08 | MTBLS5615 | MetaboLights
MetabolomicsAntibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria

Background

Antibiotic treatment has a well-established detrimental effect on the gut bacterial composition, but effects on the fungal community are less clear. Bacteria in the lumen of the gastrointestinal tract may limit fungal colonization and invasion. Antibiotic drugs t...

2020-09-28 | MTBLS1846 | MetaboLights
MetabolomicsOxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers
Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability in most patients with estrogen receptor positive breast cancers (ER + BC). By genomic and metabolomics analyses of patients' tumours, metastasis-derived patient-derived xenografts (PDX) and isogenic cell line...
2023-06-27 | MTBLS3342 | MetaboLights
UnknownArticle 4: Impact assessment of supervision performance assessment and recognition strategy (SPARS) to improve supply chain management in health facilities in Uganda: a national pre and post study.
Not available
S-EPMC7857862 | biostudies-literature
UnknownFirst regulatory inspections measuring adherence to Good Pharmacy Practices in the public sector in Uganda: a cross-sectional comparison of performance between supervised and unsupervised facilities.
Not available
S-EPMC4857441 | biostudies-literature
UnknownArticle 2: Longitudinal study assessing the one-year effects of supervision performance assessment and recognition strategy (SPARS) to improve medicines management in Uganda health facilities.
Not available
S-EPMC6033200 | biostudies-literature
GenomicsConfirmation of a founder effect in a Northern European population (FRL) of a new beta-globin variant: HBB:c.23 26dup (codons 8/9 (+AGAA))
Beta-thalassemia is a genetic disease caused by a defect in the production of the beta-like globin chain. More than 200 known different variants can lead to the disease and are mainly found in populations that have been exposed to malaria parasites. We recently described a duplication of 4 nucleotid...
EGAS00001000980 | EGA
MetabolomicsMolecular evidence of shipping noise impact on the blue mussel, a key species for the sustainability of coastal marine environments

Anthropogenic oceanic noise due to shipping has increased up to 32-fold over the last five decades, putting marine organisms at risk. While the impact of noise on marine mammals is well documented, its effect on molluscs, which hold immense economic and ecological importance, remain largely unkno...

2025-04-11 | MTBLS5678 | MetaboLights
ProteomicsLambert_P82_VS4_Chromatin_BioID_APMS_12JUL2014
This submission contains the mass spectrometry files for the manuscript by Lambert et al. that describes the use of BioID for chromatin associated protein complexes. A detail comparison to a chromatin optimized AP-MS protocol was also performed. This submission contains 39 IDA files for the followin...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-07-17 | MSV000078782 | MassIVE
ProteomicsAregger_C12ORF49_BioID_2020_TripleTOF5600
This dataset consists of 18 raw MS files and associated peak lists and result files, acquired on AB SCIEX 5600 TripleTOF mass spectrometer operated in Data Dependent Acquisition mode. Samples were generated by Michael Aregger, affinity purification and mass spectrometric acquisition was performed ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-25 | MSV000085005 | MassIVE
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