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TranscriptomicsGenome-Wide Transcriptional Effects of the Anti-Cancer Agent Camptothecin
The anti-cancer drug camptothecin inhibits replication and transcription by trapping DNA topoisomerase I (Top1) covalently to DNA in a M-bM-^@M-^\cleavable complexM-bM-^@M-^]. To examine the effects of camptothecin on RNA synthesis genome-wide we used Bru-Seq and show that camptothecin treatment aff...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-GEOD-48678 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of multiple mouse myeloma (MM) cells during intra-medullary progression in the 5T2MM mouse model
Insights into mechanisms involved during intra-medullary myeloma progression could be helpful in the better understanding of this disease and in the development of new therapeutical strategies. Herein gene expression profile of multiple myeloma (MM) cells during intra-medullary progression was inves...
ORGANISM(S): Mus musculus 
2008-03-27 | E-MEXP-186 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of immortalized LECs (imLECs)
In contrast to the migration of leukocytes from blood vessels into tissues, and the involvement of adhesion molecules and chemokines in this process, the migration of leukocytes from the tissue into lymphatic vessels is much less well understood. This can, in part be explained by the fact that murin...
ORGANISM(S): Mus musculus 
2011-03-31 | E-GEOD-28234 | biostudies-arrayexpress
TranscriptomicsHeterologous hybridization to an oligonucleotide microarray monitors differential gene expression in Pinus radiata exposed to long-term Ethephon exposure
Comparison of transcriptomes from bark, developing xylem and xylem of P. radiata saplings exposed to 0 or 1mg of Ethephon in lanolin for 1 or 8 weeks We developed an oligonucleotide microarray using sequences (mostly from Pinus taeda) from public sequence databases. These sequences were reconstitute...
ORGANISM(S): Pinus radiata 
2012-11-15 | E-GEOD-42300 | biostudies-arrayexpress
TranscriptomicsMurine HIV-gagP24 CD8 T cells: bone marrow vs Lymph node
Transcriptional profiling to examine differences resulting from priming of virus-specific CD8 T cells in draining lymph node and in bone marrow, following intradermal injection of modified virus Ankara (MVA)-HIV gag. Transcriptional profiling of mouse pentamer H2kD-AMQMLKETI (HIV-gagP24) CD8 T cells...
ORGANISM(S): Mus musculus 
2012-10-23 | E-GEOD-41736 | biostudies-arrayexpress
TranscriptomicsMicroarray expression profiling of C. elegans N2 L4 control (RNAi) vs. nhr-25 (RNAi) and N2 (Wt) vs. acs-3 (ft5) mutants
Acyl-coA synthases (ACSs) produce fatty acyl-CoAs that are used in metabolic and signaling pathways. Metazoans have a large number of ACS genes with differing expression patterns and substrate preferences, but the physiological roles of most ACS genes are unknown. Here, we focused on the C. elegans ...
ORGANISM(S): Caenorhabditis elegans 
2014-03-21 | E-GEOD-48605 | biostudies-arrayexpress
TranscriptomicsFormaldehyde-induced changes in microRNA signaling [Agilent]
MicroRNAs (miRNAs) are critical regulators of gene expression, yet much remains unknown regarding miRNA changes resulting from environmental exposures and whether they influence pathway signaling across various tissues and time. To gain knowledge on these novel topics, we set out to investigate in v...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-42393 | biostudies-arrayexpress
TranscriptomicsResponse of Rhodospirillum rubrum S1H to three pharmaceuticals
The present study explores the potential of compound-specific gene-upregulation profiles in the ubiquitous purple nonsulfur bacterium Rhodospirillum rubrum S1H as biomarkers for exposure to surface water contaminants, i.e. high production-volume pharmaceuticals. Even though the pharmaceuticals [i.e....
ORGANISM(S): Rhodospirillum rubrum 
2013-08-23 | E-GEOD-23794 | biostudies-arrayexpress
TranscriptomicsPupylated proteins in Corynebacterium glutamicum revealed by MudPIT analysis
In a manner similar to ubiquitin, the prokaryotic ubiquitin-like protein (Pup) has been shown to target proteins for degradation via the proteasome in mycobacteria. However, not all actinobacteria possessing the Pup protein also harbor a proteasome, suggesting fates for pupylated proteins other than...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2014-06-24 | E-GEOD-48038 | biostudies-arrayexpress
TranscriptomicsGene expression analysis comparing between dormant and released leaf bud from Japanese pear 'Kosui'
Dormancy of buds is a critical developmental process that allows plants to survive extreme seasonal variations in climate. Dormancy transition in leaf buds of Japanese pear leading cultivar M-bM-^@M-^XKosuiM-bM-^@M-^Y were investigated using 10 K cDNA microarray. Leaf buds collected on October (earl...
ORGANISM(S): Pyrus pyrifolia 
2013-01-22 | E-GEOD-34845 | biostudies-arrayexpress
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