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ProteomicsGolgi-ER Axis Regulates Anti-Tumor T Cell Immunotherapeutic Response
The cumulative role of cellular organelle’s in shaping the life and function of a cell has been long acknowledged. While each organelle plays a specific role in the growth and development of T cells, numerous studies have thus far focused on targeting mitochondria, endoplasmic reticulum, or lysosome...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD048141 | Pride
T cell Golgi apparatus Immunotherapy 
TranscriptomicsCortisol (Hydrocortisone) Treatment of Activated Primary Human CD8⁺ T Cells
Peripheral blood mononuclear cells (PBMCs) were isolated by density-gradient centrifugation using Ficoll-Paque Plus. CD8⁺ T cells were purified from PBMCs by immunomagnetic negative selection and cultured for a total of 8 days. Cells were initially activated for 72 h with plate-bound anti-CD3 (1 µg/...
ORGANISM(S): Homo sapiens 
2026-02-18 | E-MTAB-16635 | biostudies-arrayexpress
GenomicsGenome wide glucocorticoid receptor (GR) binding sites upon cortisol treatment in human CD8 T cells
To map genome-wide chromatin occupancy of the human glucocorticoid receptor (GR; encoded by NR3C1) in primary activated human CD8⁺ T cells, ChIP–seq was performed following physiological cortisol stimulation. CD8⁺ T cells were isolated from healthy adult donors by immunomagnetic negative selection, ...
ORGANISM(S): Homo sapiens 
2026-02-10 | E-MTAB-16594 | biostudies-arrayexpress
ProteomicsThe catalytic activity of the kinase Zap-70 mediates basal signaling and negative feedback of the T cell receptor pathway
T cell activation must be properly regulated to ensure normal T cell development and effective immune responses to pathogens and transformed cells, while avoiding autoimmunity. Our knowledge of the mechanisms controlling the fine-tuning of T cell receptor (TCR) signaling and T cell activation is sti...
ORGANISM(S): Homo sapiens (Human) 
2016-05-31 | PXD002023 | Pride
T cell Phosphoproteomics Lc-ms/ms 
TranscriptomicsAltered Hematopoietic Cell Gene Expression Precedes Development of Therapy-Related Myelodysplasia and Identifies Patients at Risk
Therapy-related myelodysplasia or acute myeloid leukemia (t-MDS/AML) is a lethal complication of cancer treatment. Although t-MDS/AML development is associated with known genotoxic exposures, its pathogenesis is not well understood and methods to predict risk of development of t-MDS/AML in individua...
ORGANISM(S): Homo sapiens 
2011-12-12 | E-GEOD-23025 | biostudies-arrayexpress
UnknownImmunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals.
Not available
S-EPMC8222233 | biostudies-literature
ProteomicsHighly Active CAR T Cells that Bind to a Juxta-Membrane Region of Mesothelin and are Not Blocked by Shed Mesothelin
Identification of the major protease sites in MSLN and preparation of a monoclonal antibody, 15B6, that binds next to cell membrane at the protease sensitive region and inhibits MSLN shedding. Mab 15B6 makes very active CAR-T cells whose activity is not blocked by shed MSLN. The 15B6 CAR-T cells hav...
ORGANISM(S): Homo sapiens (Human) 
2022-04-13 | PXD033137 | Pride
Cancer Antibody Ovarian cancer Immunotherapy Pancreatic cancer 
UnknownAutologous engineered T cell receptor therapy in advanced cancer.
Not available
S-EPMC10732691 | biostudies-literature
TranscriptomicsComparison between HuT78 parental and romidpepsin-selected cell lines
Gene expression values were determined for HuT78 parental cells and cells selected with romidpesin in the presence of P-glycoprotein inhibitors. HuT78 DpVp35 cells are maintained in 35 ng/ml romidepsin with 2.5 µg/ml verapamil and HuT78 DpP100 cells are maintained in 100 ng/ml romidepsin with 1 µM v...
ORGANISM(S): Homo sapiens 
2013-03-12 | E-GEOD-45018 | biostudies-arrayexpress
UnknownHow persistent infection overcomes peripheral tolerance mechanisms to cause T cell-mediated autoimmune disease.
Not available
S-EPMC10945823 | biostudies-literature
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