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TranscriptomicsComparison of stimulatory and inhibitory dendritic cell subsets reveals new role of DC in granulomatous infection
Myeloid dendritic cells (DC) and macrophages play an important role in pathogen sensing and antimicrobial defense. Recently we demonstrated that infection of human DC with intracellular bacterium Listeria monocytogenes (L.monocytogenes) leads to the induction of the immunoinhibitory enzyme indoleami...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-9946 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of Patients with a Variation in the TNF-alpha gene and suffering from Multiple Trauma
BACKGROUND: Patients encountering severe trauma are at risk of developing sepsis syndrome and subsequent multiple organ failure. This is often associated with fatal outcome despite survival of the initial injury. We undertook a prospective cohort study of trauma patients to examine the role of tumor...
ORGANISM(S): Homo sapiens 
2007-08-22 | E-GEOD-5760 | biostudies-arrayexpress
no omics definedTranscription profiling of Listeria monocytogenes EGD-e after heat-shock for 3, 10, 20, and 40 min
L. monocytogenes EGD-e (Glaser et al., 2001) was grown in Brain Hearth Infusion Broth (Difco) with shaking (200 rpm, New Brunswick C24KC) using 10 ml culture medium in 100 ml conical flasks. An exponentially growing culture was used to inoculate 100 ml of fresh pre-warmed BHI broth in a 500 ml flask...
ORGANISM(S): Listeria monocytogenes 
2007-10-09 | E-MEXP-1118 | biostudies-arrayexpress
TranscriptomicsPeritoneal and testicular macrophage mrna expression after exposure to UPEC CFT073
Ascending bacterial infections of the male genitourinary tract by Escherichia coli are an important cause of male infertility. Thus understanding mechanisms by which immunocompetent cells such as testicular macrophages (TM) respond to infection and how bacterial pathogens manipulate defense pathways...
ORGANISM(S): Rattus norvegicus 
2010-10-20 | E-GEOD-24780 | biostudies-arrayexpress
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