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GenomicsGenome wide profiling of RNA Pol II and CSB in CS1AN cells or wild type CSB reconstituted cells [ChIP-seq]
We report how CSB affects globally the density of RNA Pol II at TSS and how this effect correlates with the gene expression alterations observed from microarray analysis. We also show globally the distribution of CSB. RNA Pol II and CSB ChIP-Seq in CS1AN cells and CSB reconstituted wild type cells, ...
ORGANISM(S): Homo sapiens 
2014-09-22 | E-GEOD-58253 | biostudies-arrayexpress
TranscriptomicsNeoadjuvant chemotherapy modulates T cell responses in high-grade serous ovarian cancer metastases
Our data suggest that neoadjuvant chemotherapy enhances anti-cancer responses of T cells in peritoneal metastases of patients with high-grade serous ovarian cancer but does not decrease levels of immune checkpoint molecules, providing a rationale for sequential chemo-immunotherapy. tRNA was isolated...
ORGANISM(S): Homo sapiens 
2016-07-27 | E-GEOD-71340 | biostudies-arrayexpress
TranscriptomicsGene expression profile after SYT9 re-expression during differentiation of CSB-KD SH-SY5Y cells
CSB-depletion induced SH-SY5Y differentiation defects can be partially rescued by re-expression of SYT9 gene. This study characterizes the transcriptome signatures upon SYT9 re-expression in CSB-KD SH-SY5Y cells after RA treatment. The Nimblegen human 12 x 135K gene expression array was used to char...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-58072 | biostudies-arrayexpress
TranscriptomicsRegulation of gene expression by WAC/RNF20/RNF40 in HEK293A cells
WAC is a known positive regulator of (macro)autophagy. WAC also forms a complex with RNF20/RNF40 to promote H2B monoubiquitination and hence to affect transcriptional regulation. This study addresses whether the WAC/RNF20/RNF40 complex regulates autophagy through effects on gene expression. WAC, RNF...
ORGANISM(S): Homo sapiens 
2015-12-17 | E-GEOD-66475 | biostudies-arrayexpress
TranscriptomicsIn vitro activation of Btnl-1 transduced MODE-K cells with different stimuli
The experiment was designed to assess how intestinal epithelial cells respond to different soluble factors produced by intraepithelial lymphocytes (IEL) and how this response is altered when the epithelial cells express Btnl1. Total RNA of MODE-K cells transduced with Btnl1-GFP or GFP alone and stim...
ORGANISM(S): Mus musculus 
2015-03-31 | E-GEOD-63364 | biostudies-arrayexpress
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