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TranscriptomicsCo-ordinate inhibition of autism candidate genes by topoisomerase inhibitors [Seq]
Topoisomerases are necessary for the expression of neurodevelopmental genes, and are mutated in some patients with autism spectrum disorder (ASD). We have studied the effects of inhibitors of Topoisomerase 1 (Top1) and Topoisomerase 2 (Top2) enzymes on mouse cortical neurons. We find that topoisomer...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-43526 | biostudies-arrayexpress
TranscriptomicsCo-ordinate inhibition of autism candidate genes by topoisomerase inhibitors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-43900 | biostudies-arrayexpress
UnknownUbe3a unsilencer for the potential treatment of Angelman syndrome.
Not available
S-EPMC11231141 | biostudies-literature
TranscriptomicsCo-ordinate inhibiton of autism candidate genes by topoisomerase inhibitors [array]
Topoisomerases are necessary for the expression of neurodevelopmental genes, and are mutated in some patients with autism spectrum disorder (ASD). We have studied the effects of inhibitors of Topoisomerase 1 (Top1) and Topoisomerase 2 (Top2) enzymes on mouse cortical neurons. We find that topoisomer...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-43899 | biostudies-arrayexpress
ProteomicsIdentification of small molecule activators of the ubiquitin ligase E6AP/UBE3A and Angelman syndrome-derived E6AP/UBE3A variants
Genetic aberrations of the UBE3A gene encoding the E3 ubiquitin ligase E6AP underlie the development of Angelman syndrome (AS). Approximately 10 percent of AS individuals harbor UBE3A genes with point mutations, frequently resulting in the expression of full-length E6AP variants with defective E3 ac...
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD020602 | Pride
Ube3a Angelman syndrome Crosslinking coupled to mass spectrometry E6ap Small molecule activator Fluorescence polarization Xl-ms Ubiquitin ligase High-throughput screen 
UnknownAirflow obstruction, lung function, and incidence of atrial fibrillation: the Atherosclerosis Risk in Communities (ARIC) study.
Not available
S-EPMC3963836 | biostudies-literature
UnknownA conserved supergene locus controls colour pattern diversity in Heliconius butterflies.
Not available
S-EPMC1570757 | biostudies-literature
UnknownHealing the Past by Nurturing the Future-co-designing perinatal strategies for Aboriginal and Torres Strait Islander parents experiencing complex trauma: framework and protocol for a community-based participatory action research study.
Not available
S-EPMC6575864 | biostudies-literature
UnknownWhich way? Group-based smoking and vaping cessation support for Aboriginal and Torres Strait Islander women: protocol for a non-randomised type 1 hybrid implementation study.
Not available
S-EPMC12658511 | biostudies-literature
UnknownFinal Overall Survival Efficacy Results of Ivosidenib for Patients With Advanced Cholangiocarcinoma With IDH1 Mutation: The Phase 3 Randomized Clinical ClarIDHy Trial.
Not available
S-EPMC8461552 | biostudies-literature
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