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TranscriptomicsGene expression changes induced by the human aristolochic acid I in renal and hepatic tissue of mice
Aristolochic acid (AA) is the causative agent of urothelial tumours associated with aristolochic acid nephropathy and is also implicated in the development of Balkan endemic nephropathy-associated urothelial tumours. These tumours contain AA-characteristic TP53 mutations. We examined gene expression...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-18246 | biostudies-arrayexpress
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
GenomicsChIP Seq of Oct4, Nanog, H3K27me3 in Oct4+/+ and Oct4 +/- mES cells
Embryonic stem cell (ESC) pluripotency is governed by a gene regulatory network centred on the transcription factors Oct4 and Nanog. ESCs fluctuate between states of high and low Nanog expression that direct efficient or inefficient self-renewal. To date, robust self-renewing ESC states have only be...
ORGANISM(S): Mus musculus 
2013-05-07 | E-MTAB-1617 | biostudies-arrayexpress
ProteomicsHigh conservation of translationally significant RNA editing sites in hyper-editing ferns implies they are not selectively neutral
RNA editing is essential for processing transcripts in plant chloroplasts and mitochondria. Levels of RNA editing vary between lineages, but some hornworts, lycophytes and ferns have an extraordinary abundance of RNA editing. A feature of ‘hyper-editing’ species is the prevalence of RNA editing even...
ORGANISM(S): Marsilea mutica 
2025-10-27 | PXD065205 | Pride
Rna editing Masrsieal 
TranscriptomicsGene expression changes induced by Benzo[a]pyrene (BaP) in human breast carcinoma cell line MCF-7 in different phases of the cell cycle
Benzo[a]pyrene (BaP) is a widespread environmental genotoxic carcinogen that damages DNA by forming adducts. This damage with along the activation of the aryl hydrocarbon receptor (AHR) induces complex transcriptional responses in cells. To investigate whether human cells are more susceptible to BaP...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-26917 | biostudies-arrayexpress
TranscriptomicsReprogramming roadblocks are system-dependent
Since the first generation of induced Pluripotent Stem cells (iPSCs), several reprogramming systems have been used to study its molecular mechanisms. However, the system of choice largely affects the reprogramming efficiency, influencing our view on the mechanisms. Here we demonstrate that reprogram...
ORGANISM(S): Mus musculus 
2015-08-08 | E-GEOD-70816 | biostudies-arrayexpress
GenomicsOxford nanopore sequencing data from the Arabidopsis thaliana accessions Ler-0, Cvi-0 and Tanz-1
Oxford nanopore sequencing data from the Arabidopsis thaliana accessions Ler-0, Cvi-0 and Tanz-1
ORGANISM(S): Arabidopsis thaliana 
2022-08-06 | E-MTAB-12009 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of metastatic and non-metastatic osteosarcoma biopsies
Osteosarcoma (OS) is the most common primary bone tumour in children and young adults, and the second highest cause of cancer-related death in this age group. In spite of aggressive chemotherapy, disease-free survival has not improved significantly in the past 20 years, and 50% of patients subsequen...
ORGANISM(S): Homo sapiens 
2010-08-30 | E-GEOD-9508 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization and transcription profiling of human and mouse T cells in differentiation
ChIP-Chip for T-bet and GATA-3 in human Th1 and Th2 cells, gene expression profiling of human Th1 and Th2 cells and of T-cells from T-bet-deficient mice,
ORGANISM(S): Homo sapiens 
2009-10-26 | E-TABM-759 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Treponema denticola in response to environmental stresses
Whole genome expression profiles in response to different suspected stresses including heat, hypo-tonic conditions, oxygen and blood exposure were examined.
ORGANISM(S): Treponema denticola 
2010-08-01 | E-MEXP-2656 | biostudies-arrayexpress
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