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UnknownActivation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma treated with R-CHOP.
Not available
S-EPMC3871513 | biostudies-literature
ProteomicsInhibition of KDEL receptors remodels the tumor microenvironment for T cell independent tumor regression
Tumor immunotherapy is supported by low-grade inflammatory conditions at the microenvironment, triggered by immunogenic cell death (ICD). However, ICD is dampened when tumors acquire resistance, affecting immune recognition. KDEL receptors (KDELRs), through a retrograde Golgi-to-ER transport, preven...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD072994 | Pride
Kdel protein Er stress Tumor microenvironment 
ProteomicsLRIG1 engages ligand VISTA and impairs tumor-specific CD8+ T cell responses
Cancer immunotherapies boost antitumor immunity and improve the survival of cancer patients. V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an immune 20 checkpoint target but presents elusive signaling mechanisms. We report a novel VISTA binding partner, Leucine-Rich Repeats and ...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD050084 | Pride
Bottom up proteomics Proximity labelling Cancer 
ProteomicsNovel Mechanism and Therapy of Anthracycline-Induced Cardiotoxicity (AIC)
Anthracyclines are potent chemotherapeutic agents known for their efficacy in treating various cancers via inhibition of topoisomerase II alpha (TOP2A). However, their clinical use is limited due to cardiotoxicity, primarily attributed to off-target inhibition of topoisomerase II beta (TOP2B) in car...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-05 | PXD077277 | Pride
Top2b Smyd1 
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