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GenomicsChIP-seq of CTCF, RAD21, and TOP2B binding sites in three human tissue samples with hepatocellular carcinoma
The roles of topoisomerases in somatic mutagenesis in cancer are poorly understood and their DNA-binding landscape remains largely unmapped. Here we generated genome-wide DNA-binding maps of TOP2B, CTCF, and RAD21 in human hepatocellular carcinoma samples.
ORGANISM(S): Homo sapiens 
2024-02-01 | E-MTAB-13301 | biostudies-arrayexpress
ProteomicsNovel Mechanism and Therapy of Anthracycline-Induced Cardiotoxicity (AIC)
Anthracyclines are potent chemotherapeutic agents known for their efficacy in treating various cancers via inhibition of topoisomerase II alpha (TOP2A). However, their clinical use is limited due to cardiotoxicity, primarily attributed to off-target inhibition of topoisomerase II beta (TOP2B) in car...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-05 | PXD077277 | Pride
Top2b Smyd1 
GenomicsGenome wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells
TOP2B is involved in transcriptional initiation in response to nuclear hormone ligands and plays a role in transcriptional elongation. Whole genome TOP2B ChIP-seq was carried out on human MCF7 cells in the presence and absence of the nuclear hormone estradiol. Three peak calling methods were used an...
ORGANISM(S): Homo sapiens 
2015-09-21 | E-GEOD-66753 | biostudies-arrayexpress
TranscriptomicsGene expression in the wildtype and top2b-deleted cardiomyocytes with or without doxorubicin treatment
To compare expression profiles in the cardiomyocytes with wild type top2b and those with top2b deletion after in vivo treatment of mice with doxorubicin or drug vehicle Doxorubicin is widely used in modern cancer treatments, despite the advent of targeted therapy. However, a dose-dependent cardiot...
ORGANISM(S): Mus musculus 
2012-10-28 | E-GEOD-40289 | biostudies-arrayexpress
ProteomicsUuskula_P112_VS2_TOP2B_BioID_15JUN2015
This submission contains the mass spectrometry files for the manuscript by Uuskula-Reimand et al. that investigates the interactome of TOP2B using BioID and its genomic binding profile. This submission contains 18 IDA files for the following baits: empty 3XFLAG control, GFP-BirA-FLAG control, NLS-Bi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-07-10 | MSV000079188 | MassIVE
ProteomicsIdentification of phosphorylation sites in human recombinant TOP2B
Human recombinant full-length TOP2B purified from HEK293 cells were phosphorylated with Erk1 and Erk2 in vitro. After in-gel digestion, the phosphorylation sites were determined using mass spectrometry.
ORGANISM(S): Homo Sapiens (human) 
2023-11-03 | PXD040977 | JPOST Repository
GenomicsSpatial transcriptomic profiling of TOP2B-driven anthracycline-induced cardiotoxicity in mouse hearts
Spatial transcriptomic profiling of TOP2B-driven anthracycline-induced cardiotoxicity in mouse hearts
PRJNA1425298 | ENA
UnknownTOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas.
Not available
S-EPMC8818263 | biostudies-literature
GenomicsTOP2B modulates DNA supercoiling-driven chromatin contacts during transcriptional induction
TOP2B modulates DNA supercoiling-driven chromatin contacts during transcriptional induction
PRJEB101069 | ENA
UnknownAndrogen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements.
Not available
S-EPMC3157086 | biostudies-literature
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