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ProteomicsLabel free quantitative proteomics reveals survival mechanisms developed by Hypertrophic chondrocytes under ER stress
Emerging evidence implicates ER stress caused by unfolded mutant proteins in chondrocytes as the underlying pathology of chondrodysplasias. ER stress is triggered in hypertrophic chondrocytes (HCs) in a mouse model (13del) of metaphyseal chondrodysplasia type Schmid (MCDS) caused by misfolded mutan...
ORGANISM(S): Mus musculus (Mouse) 
2015-11-25 | PXD002125 | Pride
Metaphyseal chondrodysplasia type schmid Mitochondrial membrane polarity Glycolysis Calcium signaling 
ProteomicsActively synthesised proteins in human intervertebral disc
The intervertebral disc (IVD) is a joint in the spine that facilitates daily movement, comprising of the central nucleus pulposus (NP), surrounded by the annulus fibrosus (AF) and sandwiched between two cartilage endplates that function together as a unit. Changes to the IVD occur with aging, most d...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD018193 | Pride
Proteomics Dynamic proteome Intervertebral disc Silac Proteomic architecture Aging 
ProteomicsA proteomic architectural landscape of the healthy and aging human intervertebral disc
The intervertebral disc (IVD) is a joint in the spine that facilitates daily physical activity, comprising of the central nucleus pulposus (NP), surrounded by the annulus fibrosus (AF) and sandwiched between two cartilage endplates that function together as a unit. Changes to the IVD occur with agin...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD017740 | Pride
Proteomics Intervertebral disc Aging 
ProteomicsThe degradome of the human intervertebral disc
The intervertebral disc (IVD) is a joint in the spine that facilitates daily physical activity, comprising of the central nucleus pulposus (NP), surrounded by the annulus fibrosus (AF) and sandwiched between two cartilage endplates that function together as a unit. Changes to the IVD occur with agin...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD018298 | Pride
Proteomics Dynamic proteome Intervertebral disc Degradome Proteomic architecture Aging 
UnknownThe role of interleukin-2, all-trans retinoic acid, and natural killer cells: surveillance mechanisms in anti-GD2 antibody therapy in neuroblastoma.
Not available
S-EPMC5862751 | biostudies-literature
ProteomicsProteomic landscape of murine intervertebral disc reveals mechanisms involved in homeostasis and disc structure maintenance
To fully apprehend the complex mechanisms responsible for intervertebral disc (IVD) degeneration, one needs to gain a deeper understanding of what characterizes a healthy disc. Using a quantitative proteomic approach, we analyzed methodically the differences existing between IVD genders, levels and ...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD006671 | Pride
Mouse intervertebral disc Nucleus pulposus Annulus fibrosus Proteomic Homeostasis Structure maintenance 
ProteomicsSM/J mice display spontaneous early onset disc degeneration link to ion transport system and matrisome changes
To fully apprehend the complex mechanisms responsible for intervertebral disc (IVD) degeneration, one needs to gain a deeper understanding of what characterizes a good and bad intervertebral disc. Using a quantitative proteomic approach, we compared methodically the differences existing between a mo...
ORGANISM(S): Mus musculus (Mouse) 
2018-04-16 | PXD008784 | Pride
Mouse intervertebral disc Nucleus pulposus Lg/j and sm/j. Proteomic 
UnknownCapmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy.
Not available
S-EPMC11157767 | biostudies-literature
UnknownSubgroup and subtype-specific outcomes in adult medulloblastoma.
Not available
S-EPMC10723183 | biostudies-literature
UnknownSubgroup-specific structural variation across 1,000 medulloblastoma genomes.
Not available
S-EPMC3683624 | biostudies-literature
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