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TranscriptomicsLKB1/STK11 Inactivation Leads to Expansion of Pro-Metastatic Tumor Sub-Population in Melanoma
Germline mutations in LKB1 (STK11) are associated with the Peutz–Jeghers syndrome (PJS), which includes aberrant mucocutaneous pigmentation, and somatic LKB1 mutations occur in 10% of cutaneous melanoma. By somatically inactivating Lkb1 with K-Ras activation (+/- p53 loss) in murine melanocytes, we ...
ORGANISM(S): Mus musculus 
2012-06-24 | E-GEOD-34866 | biostudies-arrayexpress
UnknownPolo-like kinase1 is required for recruitment of dynein to kinetochores during mitosis.
Not available
S-EPMC3121523 | biostudies-literature
TranscriptomicsBowel expression profiles of infants with gastrointestinal conditions
We have employed whole genome microarray expression profiling to identify genes differentially expressed in neonatal bowel tissues of different gastrointestinal conditions. Bowel tissues were collected from infants who underwent surgery treatment for necrotising enterocolitis (NEC) and spontaneous i...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-46619 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiles in primary cutaneous melanoma are associated with clinically significant pathologic features
We investigated whether methylation in primary melanomas is associated with tumor pathologic features or defines subgroups of primary melanomas 47 primary cutaneous melanomas were analyzed using the Illumina GoldenGate Cancer Panel I methylation array
ORGANISM(S): Homo sapiens 
2015-06-15 | E-GEOD-54623 | biostudies-arrayexpress
UnknownExploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium.
Not available
S-EPMC11851166 | biostudies-literature
UnknownEndogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation.
Not available
S-EPMC4776467 | biostudies-literature
TranscriptomicsPGN induced transcriptional changes in human neonatal neutrophils
We have employed whole genome microarray expression profiling to identify genes differentially expressed in cord blood purified neutrophils after a short-term exposure to peptidoglycan (PGN). PGN induced gene expressions of neonatal neutrophils were measured at 4 hours. Three biological replicates w...
ORGANISM(S): Homo sapiens 
2013-09-04 | E-GEOD-40636 | biostudies-arrayexpress
UnknownProjected time to elimination of cervical cancer in the USA: a comparative modelling study.
Not available
S-EPMC8715100 | biostudies-literature
UnknownMaternal ambient air pollution, preterm birth and markers of fetal growth in Rhode Island: results of a hospital-based linkage study.
Not available
S-EPMC5879771 | biostudies-literature
TranscriptomicsThrombopoietin (TPO) protects against heart damage induced by doxorubicin and infarction in rat models
In order to examine the mechanism of TPO on cardiac protection against DOX damage, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to delineate the TPO cardioprotective mechanism against DOX-induced cardiomyopathy Dox and TPO...
ORGANISM(S): Rattus norvegicus 
2010-12-29 | E-GEOD-15449 | biostudies-arrayexpress
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