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MetabolomicsMolecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection
Postcopulatory sexual selection is recognized as a key driver of reproductive trait evolution, including the machinery required to produce endogenous nuptial gifts. Despite the importance of such gifts, the molecular composition of the non-gametic components of male ejaculates and their interactions...
2016-12-22 | MTBLS362 | MetaboLights
GenomicGenetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

Immune checkpoint inhibitors are effective cancer treatments, but molecular determinants of clinical benefit are unknown. Ipilimumab and tremelimumab are antibodies against cytotoxic T-lymphocyte antigen 4 (CTLA-4). Anti-CTLA-4 treatment prolongs overall survival in patients with melanoma. CTLA-4...

phs001041 | dbGaP
TranscriptomicsGenome-wide copy number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma
We studied 277 lymphoma samples (198 FL and 79 transformed FL [tFL]) using a single-nucleotide polymorphism array to identify the secondary chromosomal abnormalities that drive the development of FL and its transformation to diffuse large B-cell lymphoma. Affymetrix 250K NspI SNP arrays were perform...
ORGANISM(S): Homo sapiens 
2015-03-30 | E-GEOD-67385 | biostudies-arrayexpress
TranscriptomicsConvergence of Mutation and Epigenetic Alterations Identifies Common Target Genes in Breast and Colon Cancer
The identification and characterization of tumor suppressor genes has enhanced our understanding of the biology of cancer and enabled the development of new diagnostic and therapeutic modalities. Whereas in past decades, a handful of tumor suppressors have been slowly identified using techniques su...
ORGANISM(S): Homo sapiens 
2009-09-23 | E-GEOD-10613 | biostudies-arrayexpress
UnknownMulticenter Phase IB Trial of Carboxyamidotriazole Orotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anaplastic Gliomas.
Not available
S-EPMC5993168 | biostudies-literature
TranscriptomicsBreast Cancer Methylomes Establish an Epigenomic Foundation for Metastasis
Cancer-specific changes in DNA methylation can alter genetic stability, genomic structure, and gene expression. Promoter CpG island methylation can result in transcriptional silencing and plays an important role in the oncogenic process. We used genome-wide analysis to characterize the methylomes o...
ORGANISM(S): Homo sapiens 
2011-03-31 | E-GEOD-26349 | biostudies-arrayexpress
TranscriptomicsRNAcompete: a method for rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins
Metazoan genomes encode hundreds of RNA binding proteins (RBPs) but relatively few have well-defined RNA-binding preferences. Current techniques for determining RNA targets, including those involving in vitro selection and RNA co-immunoprecipitation, require significant time and labour investment. H...
ORGANISM(S): synthetic construct 
2010-05-18 | E-GEOD-15769 | biostudies-arrayexpress
UnknownInhibition of KDEL receptors remodels the tumor microenvironment for robust T cell independent tumor regression
Not available
ORGANISM(S): Mus musculus (mouse) Homo sapiens (human) 
S-BSST2345 | biostudies-other
TranscriptomicsMethylation analysis of 81 glioma clinical samples (49 CIMP+ and 32 CIMP-) and 53 cell line samples
Glioma CIMP (G-CIMP) is a powerful determinant of tumor pathogenicity but the molecular cause of G-CIMP is a fundamental question that is unresolved. Here, we show that mutation of a single gene, isocitrate dehydrogenase 1 (IDH1), directly causes the G-CIMP in gliomas by remodeling the methylome. I...
ORGANISM(S): Homo sapiens 
2012-02-16 | E-GEOD-30338 | biostudies-arrayexpress
TranscriptomicsExpression of known and predicted genes in tissues of Gallus gallus (chicken)
Expression of known and predicted genes in tissues of Gallus gallus (chicken) pooled from multiple healthy individuals. Two-colour experiments with two different tissues hybridized to each array. Each tissue is arrayed in replicate with dye swaps. Tissues: Bursa of Fabricius, Cerebellum, Cerebral co...
ORGANISM(S): Gallus gallus 
2010-06-19 | E-GEOD-12974 | biostudies-arrayexpress
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