Sort   by:  
 Page size 
TranscriptomicsModulation of gene expression in heart and liver of hibernating black bears (Ursus americanus)
We analyzed gene expression in the American black bear, Ursus americanus, using a custom 12,800 cDNA probe (BA02) microarray to detect differences in expression that occur in heart and liver during winter hibernation in comparison to summer active animals. We identified 245 genes in heart and 319 ge...
ORGANISM(S): Ursus americanus 
2011-05-10 | E-GEOD-27875 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of PBMC from HIV and HIV/TB co-infected patients
Diagnosis of TB, especially in the presence of an HIV co-infection, can be challenging when using conventional diagnostic methods. In this study, we analyzed global gene expression data from PBMC of patients that were either mono-infected with HIV or co-infected with HIV and TB in order to identify...
ORGANISM(S): Homo sapiens 
2014-03-05 | E-GEOD-50834 | biostudies-arrayexpress
TranscriptomicsDNA methylation analysis of PBMC from HIV and HIV/TB co-infected patients
Genome wide DNA methylation profiling of PBMC from South African patients either infected with HIV only or coinfected with HIV and tuberculosis (TB). The Illumina Infinium 27k Human DNA methylation Beadchip was used to obtain DNA methylation profiles from PBMC samples. Samples included 19 HIV patien...
ORGANISM(S): Homo sapiens 
2014-03-05 | E-GEOD-50835 | biostudies-arrayexpress
TranscriptomicsPreservation of bone mass and structure in hibernating black bears (Ursus americanus) through elevated expression of anabolic genes
Physical inactivity reduces mechanical load on the skeleton, which leads to losses of bone mass and strength in non hibernating mammalian species. Although bears are largely inactive during hibernation, they show no loss in bone mass and strength. To obtain insight into molecular mechanisms preventi...
ORGANISM(S): Ursus americanus 
2012-02-15 | E-GEOD-35796 | biostudies-arrayexpress
TranscriptomicsGenome wide DNA Methylation Study in Cornelia de Lange Syndrome
Differential DNA methylation was identified in CdLS, and correlates to cohesin binding as well. However, DNA methylation may only be one of several events that regulate gene expression in humans. 63 Lymphoblastoid cell lines (LCLs) from 39 CdLS probands, 2 RBS probands and 22 gender and racial match...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-18458 | biostudies-arrayexpress
TranscriptomicsImpact of aging on cell-to-cell transcriptional variability during immune stimulation
We explored how aging impacts transcriptional dynamics using single-cell RNA-sequencing to profile hundreds of CD4+ T cells from young and old mice from two divergent species. In young animals, immunological challenge drives a conserved transcriptomic switch from highly variable to tightly regulated...
ORGANISM(S): Mus musculus 
2016-07-21 | E-MTAB-4888 | biostudies-arrayexpress
Sort   by:  
 Page size