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TranscriptomicsTranscription profiling of human fibroblasts to examine diversity, topographic differentiation and positional memory
Diversity, Topographic Differentiation, and Positional Memory in Human Fibroblasts Howard Y. Chang, Jen-Tsan Chi, Sandrine Dudoit, Chanda Bondre, Matt van de Rijn, David Botstein, and Patrick O. Brown A fundamental feature of the architecture and functional design of vertebrate animals is a stroma...
ORGANISM(S): Homo sapiens 
2005-09-27 | E-SMDB-1507 | biostudies-arrayexpress
TranscriptomicsRole of NF-kB in aging
To address the role of NF-kB in aging in vivo, we utilized a well-characterized system that allows inducible and site-specific inhibition of NF-kB activity in murine skin. The hormone binding domain of the mutant estrogen receptor that is responsive to 4-hydroxytamoxifen (4-OHT) was fused to a mutan...
ORGANISM(S): Mus musculus 
2010-06-30 | E-GEOD-3845 | biostudies-arrayexpress
TranscriptomicsGenomewide view of gene silencing by small interfering RNAs
RNA interference (RNAi) is an evolutionarily conserved mechanism in plant and animal cells that directs the degradation of messenger RNAs homologous to short double-stranded RNAs termed small interfering RNA (siRNA). The ability of siRNA to direct gene silencing in mammalian cells has raised the pos...
ORGANISM(S): Homo sapiens 
2005-12-14 | E-GEOD-3825 | biostudies-arrayexpress
TranscriptomicsGenetic regulators of large-scale transcriptional signatures in cancer
Gene expression signatures encompassing dozens to hundreds of genes have been associated with many important parameters of cancer, but mechanisms of their control are largely unknown. Here we present a method based on genetic linkage that can prospectively identify functional regulators driving larg...
ORGANISM(S): Homo sapiens 
2006-03-09 | E-GEOD-4433 | biostudies-arrayexpress
UnknownUnderstanding the transcriptome through RNA structure.
Not available
S-EPMC3858389 | biostudies-literature
TranscriptomicsAnatomic demarcation by positional variation in fibroblast gene expression programs.
Data set to accompany : Anatomic demarcation by positional variation in fibroblast gene expression programs. PLoS Genet. 2006 Jul;2(7):e119. PMID: 16895450 Fibroblasts are ubiquitous mesenchymal cells with many vital functions during development, tissue repair, and disease. Fibroblasts from diffe...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-5591 | biostudies-arrayexpress
ProteomicsThe role of Xist-mediated Polycomb recruitment in the initiation of X-chromosome inactivation
The role of Xist-mediated Polycomb recruitment in the initiation of X-chromosome inactivation
ORGANISM(S): Mus musculus (Mouse) 
2019-08-29 | PXD014287 | Pride
Mouse Xist Chirp-ms 
TranscriptomicsMCF10A_MYC_PLUS_CSN5
Gene expression signatures encompassing dozens to hundreds of genes have been associated with many important parameters of cancer, but mechanisms of their control are largely unknown. Here we present a method based on genetic linkage that can prospectively identify functional regulators driving larg...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-2824 | biostudies-arrayexpress
UnknownEssential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency.
Not available
S-EPMC3921674 | biostudies-literature
TranscriptomicsEssential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency
Here we delineate the roles of RNA binding for WDR5 function on chromatin state and murine embryonic stem cell (ESC) maintenance. Examination of global transcriptional changes and mapping genome-wide transcription factors occupancy at distinct time points during the transdifferentiation process
ORGANISM(S): Mus musculus 
2014-02-12 | E-GEOD-53035 | biostudies-arrayexpress
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