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UnknownAntcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts.
Not available
S-EPMC9210827 | biostudies-literature
TranscriptomicsFoxA1 regulates sweat secretion through Best2 and Nkcc1 ion transporters
Body temperature is maintained in a narrow range in mammals, primarily controlled by sweating. In humans, the dynamic thermoregulatory organ, comprised of 2-4 million sweat glands distributed over the body, can secrete up to 4 liters of sweat per day1, thereby making it possible to withstand high te...
ORGANISM(S): Mus musculus 
2012-01-11 | E-GEOD-32347 | biostudies-arrayexpress
TranscriptomicsATAC-sequencing mice small intestinal epithelium with intestinal epithelium specific LSD1 knock out compared to wild type
To study the epigenetic regulation of intestinal epithelium we focus on the role of chromatin modulators. Lysine-specific histone demethylase 1a (KDM1A, LSD1) is one of the enzymes that can erase the H3K4me1/2 mark. To assess the role of LSD1 in intestinal epithelium we studied wild type (WT) (Villi...
ORGANISM(S): Mus musculus 
2021-03-23 | E-MTAB-8718 | biostudies-arrayexpress
UnknownKlebsiella pneumoniae K2 capsular polysaccharide degradation by a bacteriophage depolymerase does not require trimer formation.
Not available
S-EPMC10936425 | biostudies-literature
UnknownDirect characterization of intrinsic defects in monolayer ReSe2 on graphene.
Not available
S-EPMC10563845 | biostudies-literature
TranscriptomicsTranscriptome Profiling of UCL93 Kidney Epithelial Cells and CRISPR-Cas9 Knockouts for PKD1 and BICC1 Using Total RNA-Seq
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary cause of kidney failure, resulting from germline mutations in PKD1 and PKD2 in over 90% of cases. Polycystin-1 (PC-1), a cell surface receptor linked to focal adhesion proteins, plays a critical role in regulating cel...
ORGANISM(S): Homo sapiens 
2026-07-27 | E-MTAB-14624 | biostudies-arrayexpress
TranscriptomicsCalactin - a small molecule induces DNA damage and histione modification in leukemia cells
Calactin is a small molecule isolated from the Chinese herb Asclepias curassavica. We found that calactin induced DNA damage, G2/M arrest of cell cycle, and apoptosis. The calactin also increased the H2AX and Chk2 phosphorylation, which resulted in the decrease of Cdc25C and cdk1 expressions, indica...
ORGANISM(S): Homo sapiens 
2011-03-31 | E-GEOD-20928 | biostudies-arrayexpress
TranscriptomicsThe glycogen scaffolding protein PTG coordinately regulates glycogen and lipid storage
Glycogen and lipid are major storage forms of energy that are tightly regulated by hormones and metabolic signals. Here, we evaluate the role of the glycogenic scaffolding protein PTG/R5 in energy homeostasis. We demonstrate that feeding mice a high-fat diet (HFD) increases hepatic glycogen, corresp...
ORGANISM(S): Mus musculus 
2014-06-13 | E-GEOD-45319 | biostudies-arrayexpress
TranscriptomicsInsights into ulcerative colitis and ileal pouchitis from a model of stasis-induced enteric dysbiosis and genetic susceptibility
Gut dysbiosis and host genetics are implicated as causative factors in inflammatory bowel disease, yet mechanistic insights are lacking. Longitudinal analysis of ulcerative colitis patients following total colectomy with ileal anal anastomosis (IPAA) where >50% develop pouchitis, offers a unique set...
ORGANISM(S): Mus musculus 
2015-09-20 | E-GEOD-71997 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression comparison (primary central nervous system lymphoma (PCNSL) vs normal lymph node)
A genome-wide gene expression comparison between primary central nervous system lymphoma (PCNSL) and normal lymph node was performed to identify a differential exprssion and specific pathway. Experiment design: 7 PCNSL and 7 normal lymph node tissues were used for comparison.
ORGANISM(S): Homo sapiens 
2010-11-13 | E-GEOD-25297 | biostudies-arrayexpress
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