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MetabolomicsDeletion of glycerol channel aquaporin-9 (Aqp9) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db) obese mice
Deletion of the glycerol channel aquaporin-9 (Aqp9) reduces postprandial blood glucose levels in leptin receptor deficient (db/db) obese mice on a C57BL/6×C57BLKS mixed genetic background. Furthermore, shRNA mediated reduction of Aqp9 expression reduces liver triacylglycerol (TAG) accumulation in a ...
2015-09-28 | MTBLS219 | MetaboLights
MetabolomicsTwo-Channel Chemical Isotope Labeling Metabolomics Analysis of Human Fecal Samples

Global metabolomics study of the amine and carboxyl submetabolomes of 16 human fecal samples.

2026-09-23 | MTBLS13531 | MetaboLights
ModelsKim2022 - BayeshERG: A deep learning model for predicting hERG channel blockers
BayeshERG is a predictor of small molecule-induced blockade of the hERG ion channel. To increase its predictive power, the authors pretrained a bayesian graph neural network with 300,000 molecules as a transfer learning exercise. The pretraining set was obtained from Du et al, 2015, and the fine tun...
2024-08-06 | MODEL2408060001 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
TranscriptomicsTranscription profiling of chloride channel ClC-2 knock out mice with a Leukoencephalopathy-like phenotype vs.wild type
ClC-2 is a broadly expressed Cl- channel of the CLC family of Cl- channels and transporters which is abundantly expressed in brain. Here it was proposed to participate in lowering the cytoplasmic Cl- concentration of neurons, a process that establishes an inhibitory response to the neurotransmitters...
ORGANISM(S): Mus musculus 
2008-05-01 | E-MEXP-1028 | biostudies-arrayexpress
GenomicsAlteromonas mediterranea 615 strain:'English Channel 615'
Alteromonas mediterranea 615 strain:'English Channel 615' Genome sequencing
PRJNA192229 | ENA
ProteomicsThe calcium-permeable channel OSCA1.3 regulates plant stomatal immunity
Perception of biotic and abiotic stresses often leads to stomatal closure in plants. Rapid influx of calcium ions (Ca2+) across the plasma membrane plays an important role in this response, but the identity of Ca2+ channels involved has remained elusive. Here, we report that the Arabidopsis thaliana...
ORGANISM(S): Arabidopsis Thaliana 
2020-09-11 | PXD020852 | panorama
GenomicsAlteromonas macleodii str. 'English Channel 673'
Alteromonas macleodii str. 'English Channel 673' genome sequencing project
PRJNA65407 | ENA
TranscriptomicsGene expression in mouse retinas with cone cyclic nucleotide gated channel deficiencies
The cone photoreceptor cyclic nucleotide-gated (CNG) channel is essential for central and color vision and visual acuity. Mutations in the channel subunits CNGA3 and CNGB3 are associated with achromatopsia and cone dystrophy. We investigated the gene expression profiles in mouse retina with CNG ch...
ORGANISM(S): Mus musculus 
2013-07-03 | E-GEOD-40982 | biostudies-arrayexpress
ProteomicsRegulation of the PKD2 channel function and associated disease phenotypes by RASSF4
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenic genetic disorders, caused by mutations in receptor PKD1 or ion channel PKD2, and is characterized by progressive renal cyst development with additional hepatic and extrarenal manifestations. As effective treatme...
ORGANISM(S): Homo Sapiens 
2026-02-13 | PXD074819 |
ProteomicsSelective Binding of a Toxin and Phosphatidylinositides to a Mammalian Potassium Channel
G-protein-gated inward rectifying potassium channels (GIRKs) require Gβγ subunits and phosphorylated phosphatidylinositides (PIPs) for gating. Although studies have provided insight into these interactions, the mechanism of how these events are modulated by Gβγ and the binding affinity between PIPs ...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-02 | PXD012894 | Pride
Potassium channel Pip2 Lipid selectivity Lipid binding Girk2 Phosphorylation 
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