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ProteomicsSelective Binding of a Toxin and Phosphatidylinositides to a Mammalian Potassium Channel
G-protein-gated inward rectifying potassium channels (GIRKs) require Gβγ subunits and phosphorylated phosphatidylinositides (PIPs) for gating. Although studies have provided insight into these interactions, the mechanism of how these events are modulated by Gβγ and the binding affinity between PIPs ...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-02 | PXD012894 | Pride
Potassium channel Pip2 Lipid selectivity Lipid binding Girk2 Phosphorylation 
GenomicsSynergistic effects of intermittent ethanol exposure and increased GIRK2 expression in NGN2 neurons
Synergistic effects of intermittent ethanol exposure and increased GIRK2 expression in NGN2 neurons
PRJNA1026571 | ENA
TranscriptomicsSynergistic effects of intermittent ethanol exposure and increased GIRK2 expression in NGN2 neurons
Increased expression of G-coupled Inwardly Rectifying Potassium Channel Subunit 2 (GIRK2) has been linked to an electrophysiological endophenotype for alcohol use disorder. We have increased GIRK2 expression in human glutamatergic (NGN2-induced) neurons using two distinct strategies (CRISPRa targeti...
ORGANISM(S): Homo sapiens 
2023-11-01 | GSE244985 | GEO
TranscriptomicsAlcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons
Synonymous and noncoding single nucleotide polymorphisms (SNPs) in the KCNJ6 gene, encoding G protein-gated inwardly rectifying potassium (GIRK2) channel subunit 2, have been linked with increased electroencephalographic frontal theta event-related oscillations (ERO) in subjects diagnosed with alcoh...
ORGANISM(S): Homo sapiens 
2022-10-07 | GSE203530 | GEO
GenomicsAlcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons
Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons
PRJNA841230 | ENA
UnknownMolecular mechanism of GIRK2 channel gating modulated by cholesteryl hemisuccinate.
Not available
S-EPMC11527606 | biostudies-literature
UnknownUpregulated GIRK2 Counteracts Ethanol-Induced Changes in Excitability and Respiration in Human Neurons.
Not available
S-EPMC11026340 | biostudies-literature
UnknownCooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels.
Not available
S-EPMC4866826 | biostudies-literature
UnknownAlcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons.
Not available
S-EPMC9542475 | biostudies-literature
UnknownStructural insights into GIRK2 channel modulation by cholesterol and PIP2.
Not available
S-EPMC8436891 | biostudies-literature
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