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ProteomicsPhosphorylation of Hsp90 on serine residues in the charged linker modulates binding to interacting proteins and has implications for overall Hsp90β conformation (limited proteolysis experiment)
The charged linker region in Hsp90 has been shown to be important for Hsp90 function and global conformation. In humans, two serines located in the charged linker region are constitutively phosphorylated in vivo. In order to gain knowledge on the possible effect of these phosphorylation sites on Hsp...
ORGANISM(S): Homo sapiens (Human) 
2021-07-07 | PXD025878 | Pride
Hsp90 Limited proteolysis Charged linker Phosphorylation 
UnknownThe Charged Linker Modulates the Conformations and Molecular Interactions of Hsp90.
Not available
S-EPMC8048802 | biostudies-literature
UnknownPhosphorylation in the Charged Linker Modulates Interactions and Secretion of Hsp90β.
Not available
S-EPMC8304327 | biostudies-literature
UnknownHsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain.
Not available
S-EPMC8459299 | biostudies-literature
UnknownThe charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function.
Not available
S-EPMC4273377 | biostudies-literature
ProteomicsPhosphorylation of Hsp90 on serine residues in the charged linker modulates binding to interacting proteins and has implications for overall Hsp90β conformation
Serine residues in the charged linker region of human Hsp90beta are highly phoshporylated in vivo. Mutation of these residues to alanines resulted in altered binding of many Hsp90beta interactors. This project contains the data and searches related to co-immunoprecipitation experiments with wild-typ...
ORGANISM(S): Homo sapiens (Human) 
2021-07-07 | PXD025873 | Pride
Hsp90 Phosphorylation Interactome 
UnknownOptimizing PSMA-617-based inhibitors through charged linker modifications: Insights into structure-activity relationships.
Not available
S-EPMC12775819 | biostudies-literature
UnknownA novel PSMA-targeting tracer with highly negatively charged linker demonstrates decreased salivary gland uptake in mice compared to [68Ga]Ga-PSMA-11.
Not available
S-EPMC10828251 | biostudies-literature
ProteomicsTRIM72 cross-linked by the higher-order assembly on the negatively charged liposome surface
Plasma membrane repair is a rapid cellular response for resealing of membrane for cell survival. In the early step of repair process, TRIM72 is known to a key initiator for facilitating patch membrane to the damaged membrane site. When acute membrane injury happens, TRIM72 is also known to sensitive...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD024946 | Pride
Cx-ms Trim72 Lc-ms/ms 
UnknownCharged residues in the H-NS linker drive DNA binding and gene silencing in single cells.
Not available
S-EPMC5703333 | biostudies-literature
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