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GenomicsCo-activation of GR and NF-kB leads to extensive rearrangemnet of their binding sites and target genes
Global identification of activated GR and p65 binding sites and target genes using ChIP-seq in HeLa B2 cells. generation genome-wide chromatin state-maps of GR, p65 and RNAPII in HeLa B2 cells under conditions 1) DMSO (control); 2) TA 1M-BM-5M 4hr; 3) TNFM-NM-1 10ng/ml ; 4) TA 1M-BM-5M 4hr at at th...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-24518 | biostudies-arrayexpress
TranscriptomicsDual IRE1 RNase functions dictate glioblastoma development
The transcriptome dataset has been used to validate on a GBM patient cohort (n=117) the IRE1-dependent gene expression signature identified in U87 cell line.
ORGANISM(S): Homo sapiens 
2018-01-09 | E-MTAB-6326 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of primary human cancer associated fibroblasts isolated from breast cancer tissue
Primary human cancer associated fibroblasts (CAFs) were isolated and cultivated (up to passage 10). CAFs were sequenced to find differences in their respective gene expression patters.
ORGANISM(S): Homo sapiens 
2021-02-03 | E-MTAB-10075 | biostudies-arrayexpress
TranscriptomicsRip-Chip profiling of HnRNP A1 nuclear complexes in HuR WT and HuR KO cells
Post-transcriptional regulatory networks are dependent on the interplay of many RNA-binding proteins having a major role in mRNA processing events in mammals. We have been interested in the concerted action of the two RNA-binding proteins hnRNP A1 and HuR, both stable components of immunoselected hn...
ORGANISM(S): Mus musculus 
2013-11-01 | E-GEOD-49225 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of two human non-small-cell lung cancer cell lines in response to SN1 methylating-agents treatment
Methylating agents of SN1 type constitute a widely used class of anticancer drugs, the effect of which on human non-small-cell lung cancer (NSCLC) has not been adequately studied. We thus studied the effect of N-methyl-N-nitrosourea (MNU), a model SN1 methylating agent, on two human NSCLC cell lines...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-65933 | biostudies-arrayexpress
TranscriptomicsBRAF paradox breakers PLX8394 and PLX7904 comparison to BRAF inhibitor PLX4720 effect on BRAF V600Ε mutant colorectal adenocarcinoma cells
Genomic analysis on RKO cells treated with PLX7904, PLX8394 and PLX4720 to reveal gene expression patterns. The goal is to investigate the potential of the novel BRAF inhibitors-paradox breakers to impede colorectal cancer cells proliferation, using human cell lines bearing the BRAFV600E mutation.
ORGANISM(S): Homo sapiens 
2021-01-14 | E-MTAB-9014 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of mouse macrophage RAW 264.7 cells upon treatment with dexamethasone or the glucocorticoid receptor modulator AZD9567 in the presence or absence of inflammatory response.
The aim of the experiment was to gain insight into the selective anti-inflammatory action of the glucocorticoid receptor modulator AZD9567 in comparison with the classical synthetic glucocorticoid dexamethasone. To this end, the transcriptional profile of macrophage RAW 264.7 cells treated with dexa...
ORGANISM(S): Mus musculus 
2023-06-30 | E-MTAB-12816 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of Human Umbilical Vein Endothelial Cells (HUVEC) in response to compound treatment
Human Umbilical Vein Endothelial Cells were treated with three newly synthesized compounds and DMSO as vehicle. Total RNA was isolated 6 and 24h after treatment and gene expression analysis was performed. Three independent experiments were performed, corresponding to rep1, rep2 and rep3. Experiment ...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-75588 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Colo-205 and RKO colon adenocarcinoma cell lines treated with Novel 2-Acetamido, 6-Carboxamide Substituted Benzothiazole Derivatives as Potential BRAFV600E Inhibitors and PLX4720
Two human colorectal adenocarcinoma cell lines (Colo-205 and RKO) were treated with PLX4720 and newly synthesized 2-Acetamido, 6-Carboxamide Substituted Benzothiazole Derivatives, as potential BRAF V600E inhibitors; IDK142, IDK145, IDK133 and DMSO as control.
ORGANISM(S): Homo sapiens 
2023-12-19 | E-MTAB-13097 | biostudies-arrayexpress
UnknownIRE1 activity prognosticates prostate cancer and is a mediator of epithelial lineage control.
Not available
S-SCDT-10_1038-S44321-026-00490-W | biostudies-other
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