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TranscriptomicsTranscription profiling of different sub-types of mouse dendritic cells to study the functional relationships and properties of these cells.
The functional relationships and properties of different sub-types of dendritic cells (DC) remain largely undefined. We used a global gene profiling approach to determine gene expression patterns among murine splenic CD11c high DC subsets in an effort to better characterise these cells.
ORGANISM(S): Mus musculus 
2007-09-11 | E-GEOD-339 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human macrophages and dendritic cells exposed to phylogenetically distinct parasites
Monocyte-derived dendritic cells (DC) and macrophages (MΦ) generated in vitro from the same individual blood donors were exposed to five different pathogens, and gene expression profiles were assessed by microarray analysis. Responses to Mycobacterium tuberculosis and to phylogenetically distinct ...
ORGANISM(S): Homo sapiens 
2007-12-13 | E-GEOD-360 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human stemic juvenile idiopathic arthritis, , systemic lupus erythematosus,, type I diabetes, metastatic melanoma, acute infections, or liver-transplant recipients undergoing immunosuppressive therapy (n = 37)
The analysis of patient blood transcriptional profiles offers a means to investigate the immunological mechanisms relevant to human diseases on a genome-wide scale. In addition, such studies provide a basis for the discovery of clinically relevant biomarker signatures. We designed a strategy for mic...
ORGANISM(S): Homo sapiens 
2008-10-04 | E-GEOD-11907 | biostudies-arrayexpress
UnknownThe Blood Transcriptome of Experimental Melioidosis Reflects Disease Severity and Shows Considerable Similarity with the Human Disease.
Not available
S-EPMC4576736 | biostudies-literature
TranscriptomicsWhole Blood Transcriptional Modules generated on Illumina Hu-6 V2 Beadchips
This dataset was used to establish whole blood transcriptional modules (n=260) that represent groups of coordinately expressed transcripts that exhibit altered abundance within individual datasets or across multiple datasets. This modular framework was generated to reduce the dimensionality of whol...
ORGANISM(S): Homo sapiens 
2014-03-11 | E-GEOD-29536 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human blood leukocytes to discriminate patients with acute infections
Each infectious agent represents a unique combination of pathogen-associated molecular patterns that interact with specific pattern-recognition receptors expressed on immune cells. Therefore, we surmised that the blood immune cells of individuals with different infections might bear discriminative t...
ORGANISM(S): Homo sapiens 
2009-03-13 | E-GEOD-6269 | biostudies-arrayexpress
TranscriptomicsA Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients' Plasma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-03-17 | E-GEOD-49758 | biostudies-arrayexpress
TranscriptomicsCD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions
Plasmacytoid dendritic cells (pDCs) are key regulators of anti-viral immunity. They rapidly secrete IFN-alpha and cross-present viral antigens thereby launching adaptive immunity. Here we show that activated human pDCs inhibit replication of cancer cells, and kill them in a contact dependent fashion...
ORGANISM(S): Homo sapiens 
2009-05-21 | E-GEOD-15215 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiles in Blood of patients with Tuberculosis - Longitudinal Study
The aim of the longitudinal analysis was to examine the transcriptional blood profile of active TB patients at the time of recruitment (before drug treatment) and then subsequently at specific time points after drug treatment to determine whether the signature is extinguished with treatment and when...
ORGANISM(S): Homo sapiens 
2010-08-11 | E-GEOD-19435 | biostudies-arrayexpress
TranscriptomicsBlood Transcriptional Profiles in Human Active and Latent Tuberculosis
This series regroups different datasets (training set, test set, validation set, longitudinal set, separated cell set) to identify and characterise a specific transcriptional signature for patients with active TB, distinct from patients with latent TB and healthy controls. The training set dataset w...
ORGANISM(S): Homo sapiens 
2010-08-11 | E-GEOD-19491 | biostudies-arrayexpress
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