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ProteomicsAnalysis of CHCHD2 binding proteins in hepatocyte
Here we are using proteomics analyses to try to identify proteins binding to CHCHD2.
ORGANISM(S): Mus musculus (Mouse) 
2025-02-28 | PXD059794 | Pride
Chchd2 Hepatocyte Co-ip 
GenomicsCHCHD2 Mutant Mice Link Mitochondrial Deficits to PD Pathophysiology
CHCHD2 Mutant Mice Link Mitochondrial Deficits to PD Pathophysiology
PRJNA1334325 | ENA
GenomicsCHCHD2 gene KO effect in iPSC drived motor neurons
CHCHD2 gene KO effect in iPSC drived motor neurons
PRJNA552481 | ENA
ProteomicsMutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure
Expansion of the poly-glutamine (Q) tract in the protein Huntingtin (HTT) causes the neurodegenerative disorder Huntington’s disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain mechanistic insights into the neurodevelopmental impact of human mHTT, we e...
ORGANISM(S): Homo sapiens (Human) 
2024-06-21 | PXD041846 | Pride
Huntington’s disease Huntingtin (htt) Brain development 
OtherCHCHD2 Mutant Mice Link Mitochondrial Deficits to PD Pathophysiology
Mitochondrial dysfunction is a hallmark of Parkinson’s disease (PD), but the mechanisms by which it drives autosomal dominant and idiopathic forms of PD remain unclear. To investigate this, we generated and performed a comprehensive phenotypic analysis of a knock-in mouse model carrying the T61I mut...
ORGANISM(S): Mus musculus 
2025-10-02 | GSE309202 | GEO
GenomicsMutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure
Mutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure
PRJNA1137078 | ENA
Genomics
Chip-sequence of CHCHD2
PRJNA889227 | ENA
GenomicsCortical organoids reveal human-specific role of METTL5 in neurodevelopment via regulation of CHCHD2
Cortical organoids reveal human-specific role of METTL5 in neurodevelopment via regulation of CHCHD2
PRJNA1454832 | ENA
GenomicsMutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure [organoids]
Mutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure [organoids]
PRJNA978533 | ENA
GenomicsMutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure [NGN2]
Mutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure [NGN2]
PRJNA978567 | ENA
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