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PD is the second most common neurodegenerative disease worldwide with growing prevalence. MPTP is a neurotoxin which causes the appearance of Parkinson's disease (PD) pathology. The involvement of the cholinergic system in PD has been identified decades ago and anti-cholinergic drugs were upon the...
ORGANISM(S): Mus musculus 
Intergenerational genomic DNA methylation patterns in mouse hybrid strains Reduced representation bisulfite sequencing from mouse liver, using MspI restriction enzyme, and selecting ~100-300bp size fraction.
ORGANISM(S): Mus musculus 
Targeted protein degradation refers to the use of small molecule inducers of ubiquitin-dependent degradation of proteins and enables the development of drugs to previously inaccessible targets. Degrader development is an empirical process due to a poor understanding of the key properties that requi...
ORGANISM(S): Homo sapiens (Human) 
2021-04-06 | PXD021240 | Pride
Targeted protein degradation refers to the use of small molecule inducers of ubiquitin-dependent degradation of proteins and enables the development of drugs to previously inaccessible targets. Degrader development is an empirical process due to a poor understanding of the key properties that requi...
ORGANISM(S): Homo sapiens (Human) 
2021-04-06 | PXD019168 | Pride
Targeted protein degradation refers to the use of small molecule inducers of ubiquitin-dependent degradation of proteins and enables the development of drugs to previously inaccessible targets. Degrader development is an empirical process due to a poor understanding of the key properties that requi...
ORGANISM(S): Homo sapiens (Human) 
2021-04-06 | PXD019143 | Pride
Targeted protein degradation refers to the use of small molecule inducers of ubiquitin-dependent degradation of proteins and enables the development of drugs to previously inaccessible targets. Degrader development is an empirical process due to a poor understanding of the key properties that requi...
ORGANISM(S): Homo sapiens (Human) 
2021-04-06 | PXD019242 | Pride
Targeted protein degradation refers to the use of small molecule inducers of ubiquitin-dependent degradation of proteins and enables the development of drugs to previously inaccessible targets. Degrader development is an empirical process due to a poor understanding of the key properties that requi...
ORGANISM(S): Homo sapiens (Human) 
2021-05-25 | PXD019142 | Pride
Targeted protein degradation refers to the use of small molecule inducers of ubiquitin-dependent degradation of proteins and enables the development of drugs to previously inaccessible targets. Degrader development is an empirical process due to a poor understanding of the key properties that requi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD021313 | Pride
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