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TranscriptomicsThe Mitochondrial Calcium Uniporter controls skeletal muscle mass in vivo
Muscle atrophy contributes to the poor prognosis of many physiopathological conditions, but pharmacological therapies are still limited. Muscle activity leads to major swings in mitochondrial [Ca2+] which control aerobic metabolism, cell death and survival pathways. We have investigated in vivo the ...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-60931 | biostudies-arrayexpress
TranscriptomicsMicrogenomic Analysis in Skeletal Muscle: Expression Signatures of Individual Fast and Slow Myofibers
Background: skeletal muscle is a complex, versatile tissue composed of a variety of functionally diverse fiber types. Although the biochemical, structural and functional properties of myofibers have been the subject of intense investigation for the last decades, understanding molecular processes reg...
ORGANISM(S): Mus musculus 
2011-07-20 | E-GEOD-23244 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of genes regulating the mitochondrial dNTP pool in muscle cells.
Mutations in genes involved in dNTP metabolism can lead to tissue-specific mitochondrial depletion syndromes (MDS), likely because the expression of key enzymes is reduced to critical levels in post mitotic cells. Our goal was to establish an in vitro skeletal muscle cell model to study the muscle s...
ORGANISM(S): Mus musculus 
2013-03-08 | E-GEOD-41877 | biostudies-arrayexpress
TranscriptomicsInvolvement of miRNAs in the Regulation of Muscle Wasting during Catabolic Conditions.
Loss of muscle proteins and the consequent weakness has important clinical consequences in diseases such as cancer, diabetes, chronic heart failure and in ageing. In fact, excessive proteolysis causes cachexia, accelerates disease progression and worsens life expectancy. Muscle atrophy involves a co...
ORGANISM(S): Mus musculus 
2014-07-15 | E-GEOD-51648 | biostudies-arrayexpress
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