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MetabolomicsDynamic change of IDO1 activity predicts survival in patients with unresectable stage III NSCLC and chemoradiotherapy

OBJECTIVES: High activity of Indoleamine 2,3-dioxygenase1 (IDO1) in lung cancer patients converts tryptophan (Trp), which is the essential amino acid for T cell metabolism, to kynurenine (Kyn) and consequently suppresses anti-tumor immune responses. We aimed to track the dynamics...

2022-08-05 | MTBLS5267 | MetaboLights
TranscriptomicsGenome profile of human rectal tumors and response to neoadjuvant chemoradiotherapy
Background: Neoadjuvant chemoradiotherapy (NCRT) is the treatment of choice in advanced rectal cancer, even though there are many patients who will not benefit from it. There are still no effective methods for predicting which patients will respond or not. The present study aimed to define the genom...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-25885 | biostudies-arrayexpress
ProteomicsProteome analysis of human serum from the esophageal cancer patient before preoperative chemoradiotherapy
To identify a biomarker that can predict the response of preoperative chemoradiotherapy (PCRT). Twenty-five serum samples from patents with esophageal cancer before PCRT (responder = 13, non-responder = 12) were analyzed by quantitative proteomics.
ORGANISM(S): Homo Sapiens (human) 
2020-02-21 | PXD012819 | JPOST Repository
TranscriptomicsMembranous Expression of Ectodomain Isoforms of the Epidermal Growth Factor Receptor (EGFR) Predicts Outcome after Chemoradiotherapy of Lymph Node Negative Cervical Cancer
We compared the prognostic significance of ectodomain isoforms of the epidermal growth factor receptor (EGFR), which lack the tyrosine kinase (TK) domain, with that of the full length receptor and its autophosphorylation status in cervical cancers treated with conventional chemoradiotherapy. We furt...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-29817 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rectal adenocarcinomas biopsied before and after pre-operative short-course radiotherapy or 5-flurouracil-based chemoradiotherapy
The molecular mechanisms of clinical response or resistance to therapy were evaluated in colorectal cancer patients in a prospective biomarker discovery project. Rectal adenocarcinomas, biopsied before (diagnostic biopsy) and after (surgical resection) pre-operative short-course radiotherapy [RT] or...
ORGANISM(S): Homo sapiens 
2009-11-10 | E-MEXP-1901 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human squamous cell carcinomas to predict response to neoadjuvant chemoradiotherapy in oesophageal cancer patients
To use gene expression profiles to predict response to neoadjuvant chemoradiotherapy in oesophageal cancer patients.
ORGANISM(S): Homo sapiens 
2008-02-08 | E-MEXP-426 | biostudies-arrayexpress
TranscriptomicsIntegrative analysis of DCE-MRI and gene expression profiles in construction of a gene classifier for assessment of hypoxia-related risk of chemoradiotherapy failure in cervical cancer
We have previously identified a prognostic 31-gene expression signature in locally advanced cervical cancer that is associated with tumor hypoxia and reflected by the dynamic contrast enhanced magnetic resonance (DCE-MR) image parameter ABrix. To bring the signature closer to clinical use, we here a...
ORGANISM(S): Homo sapiens 
2016-03-29 | E-GEOD-72723 | biostudies-arrayexpress
TranscriptomicsMiRNA expression arrays from esophageal squamous cell carcinomas with different neoadjuvant chemoradiotherapy response
Preoperative chemoradiotherapy (CRT) followed by surgery has been proved to improve esophageal squamous cell carcinoma (ESCC) patients’ survival in comparison with surgery alone. However, the outcomes of CRT are heterogeneous, and no clinical or pathological method could predict CRT response. We ai...
ORGANISM(S): Homo sapiens 
2015-07-27 | E-GEOD-59974 | biostudies-arrayexpress
ProteomicsProteomics study aiming to characterize the molecular profile of response to Colorectal Cancer chemoradiotherapy
Protromics analysis of 20 FFPE colorectalcancer tumors obtained from 10 patients before and after chemoradiotherapy. The patients are divided in two groups, 5 responded to therapy and 5 did not respond.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-11 | MSV000088349 | MassIVE
TranscriptomicsPrediction of sensitivity of rectal cancer cells in response to preoperative chemoradiotherapy by DNA microarray analysis of gene expression profiles.
Samples were prospectively collected during colonoscopic examination from 46 rectal cancer patients before starting preoperative chemoradiotherapy. The expression profiles were determined using Affymetrix Human Genome U133 Plus 2.0 arrays. Comparison between the sample groups allow to identify a set...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-35452 | biostudies-arrayexpress
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