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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
MetabolomicsPseudomonas sp. Strain 273 Incorporates Organofluorine into the Lipid Bilayer during Growth with Fluorinated Alkanes
Anthropogenic organofluorine compounds are recalcitrant, globally distributed, and a human health concern. Although rare, natural processes synthesize fluorinated compounds, and some bacteria have evolved mechanisms to metabolize organofluorine compounds. Pseudomonas sp. strain 273 grows with...
2022-06-06 | MTBLS3893 | MetaboLights
UnknownInstitutional Special Needs Plans In Nursing Homes: Substantial Enrollment Growth But Low Availability, 2006-21.
Not available
S-EPMC11722931 | biostudies-literature
MetabolomicsAn interoperability framework for multicentric breath metabolomic studies
Exhaled breath contains valuable information at the molecular level and offers promising potential for precision medicine. However, few breath tests transition to routine clinical practice, partly because of the missing validation in multicenter trials. Therefore, we developed and applied an interop...
2022-10-27 | MTBLS5657 | MetaboLights
MetabolomicsClenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells
Activation of the sympathetic nervous system causes pronounced metabolic changes that are mediated by multiple adrenergic receptor subtypes. Systemic treatment with β2-adrenergic receptor agonists results in multiple beneficial metabolic effects, including improved glucose homeostasis. To...
2022-08-26 | MTBLS467 | MetaboLights
UnknownMercaptopurine Ingestion Habits, Red Cell Thioguanine Nucleotide Levels, and Relapse Risk in Children With Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group Study AALL03N1.
Not available
S-EPMC5455766 | biostudies-literature
TranscriptomicsChromosomal Fragile Site FRA16D tumor suppressor gene Wwox contributes to aerobic metabolism and oxidative stress response
The WWOX gene spans chromosomal fragile site FRA16D, a region of DNA instability in cancer. While WWOX has some tumor suppressor characteristics, its normal role and functional contribution to cancer are unclear. Drosophila homozygous Wwox mutants are viable with no discernable phenotype. Drosophila...
ORGANISM(S): Drosophila melanogaster 
2010-12-07 | E-GEOD-22689 | biostudies-arrayexpress
ProteomicsIdentification of a novel, tunable interface in the S.pombe HP1 protein, Swi6, that underpins epigenetic inheritance.
HP1 proteins bind dynamically to H3K9 methylation and are essential for establishing and maintaining transcriptionally silent epigenetic states, known as heterochromatin. HP1 proteins can dimerize, forming a binding interface that interacts with and recruits diverse chromatin-associated factors. HP1...
ORGANISM(S): Schizosaccharomyces pombe 
2024-08-10 | PXD047651 | Pride
Tmt-ms Epigenetics Quantip 
UnknownCATCH-UP vaccines: protocol for a randomized controlled trial using the multiphase optimization strategy (MOST) framework to evaluate education interventions to increase COVID-19 vaccine uptake in Oklahoma.
Not available
S-EPMC10265558 | biostudies-literature
ProteomicsNoncoding dsRNA induces Retinoic Acid synthesis to stimulate regeneration
We uncover a novel mechanism whereby developmental pathways are reactivated in adults to promote regeneration.
ORGANISM(S): Homo sapiens (Human) 
2019-05-23 | PXD013854 | Pride
Regeneration Retinoic acid Noncoding dsrna 
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