Sort   by:  
 Page size 
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
TranscriptomicsComplete genome sequence of Vibrio parahaemolyticus CHN25 and transcriptomic analysis of cold shock proteins of VpaCspA and VpaCspD in the adaptation of low temperature growth
To investigate low-temperature tolerance of the bacterium, three in-frame gene deletion mutants of VpacspA and VpacspD were constructed using homologous recombination method. When compared to the wild type strain, the growth of ΔVpacspA mutant was strongly repressed at 10 0C, whereas the deletion of...
ORGANISM(S): Vibrio parahaemolyticus 
2015-02-18 | E-GEOD-65998 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling reveals roles of meristem regulators and polarity genes during multicellular fruit trichome development in cucumber (Cucumis sativus L.).
Trichomes are the hair-like structures that are widely present on the surface of aerial organs and function in plant defense against biotic and abiotic stresses. Previous studies focus on the single cell trichomes in Arabidopsis and cotton, or multicellular glandular trichomes in tomato, but the dev...
ORGANISM(S): Cucumis sativus 
2014-07-01 | E-GEOD-49607 | biostudies-arrayexpress
MetabolomicsParabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a
Gut microbiota plays a key role in insulin resistance (IR). Here we perform a case-control study of Chinese adults (ChiCTR2200065715) and identify that Parabacteroides distasonis is inversely correlated with IR. Treatment with P. distasonis improves IR, strengthens intestinal integrity, and reduces ...
2023-11-01 | MTBLS7943 | MetaboLights
UnknownSoliton formation and spectral translation into visible on CMOS-compatible 4H-silicon-carbide-on-insulator platform.
Not available
S-EPMC9726892 | biostudies-literature
TranscriptomicsDisruption of Ttll5/Stamp gene (Tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2 associated modulatory protein gene) in male mice causes sperm malformation and infertility
Tubulin tyrosine ligase-like family member 5 (TTLL5/STAMP) has multiple activities in cells. TTLL5 is one of 13 TTLLs, has polyglutamylation activity, augments the activity of p160 coactivators (SRC-1 and TIF2) in glucocorticoid receptor-regulated gene induction and repression, and displays steroid-...
ORGANISM(S): Mus musculus 
2013-03-28 | E-GEOD-45546 | biostudies-arrayexpress
ProteomicsSS18 regulates pluripotent-somatic transition through phase separation
The transition from pluripotent to somatic states marks a critical event in mammalian development, but remains largely unresolved. Here we report the identification of SS18 as a regulator for pluripotent to somatic transition or PST by CRISPR-based whole genome screens. Mechanistically, SS18 forms m...
ORGANISM(S): Mus Musculus 
2021-05-23 | PXD026208 |
ProteomicsIdentification of proteins differentially regulated by indisulam in AGS cells using label-free quantitative proteomics
In this project, we used label-free quantitative proteomics to identify proteins that are differentially regulated by indisulam in the gastric cancer AGS cell line.
ORGANISM(S): Homo Sapiens 
2022-09-17 | PXD036835 |
TranscriptomicsTranscriptome sequencing of Ovis aries
We have completed the high quality reference genome for domestic sheep (Oar v3.1) and performed a detailed survey of gene expression across different tissues. RNA-seq data of 7 tissue types from the reference female Texel and skin tissue from a Gansu alpine fine wool sheep were sequenced. Here is t...
ORGANISM(S): Ovis aries 
2014-06-06 | E-GEOD-56643 | biostudies-arrayexpress
Sort   by:  
 Page size