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Using basal‐like untransformed cells, MCF10A, as a model system, data from our laboratory showed that both mRNAs and microRNAs exhibit dynamic changes in expression following EGF stimulation (Amit et al, 2007; Avraham et al, 2010; Kostler et al, 2013). We further demonstrated that the inducible mRNA...
ORGANISM(S): Homo sapiens 
The long non coding RNA LIMT was found in our study to inhibit cellular migration in vitro and to inhibit colonization of mammary tumorigenic cells in lungs of mice in vivo. In order to uncover the mechanism enabling these tumor suppressive functions of LIMT the expression of this lncRNA was knocked...
ORGANISM(S): Homo sapiens 
Signaling cascades during adipogenesis culminate in the expression of two essential adipogenic factors, PPARγ and C/EBPα. Here we demonstrate that the IRE1α-XBP1 pathway, the most conserved branch of the unfolded protein response (UPR), is indispensable for adipogenesis. Indeed, XBP1-deficient ...
ORGANISM(S): Mus musculus 
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