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ProteomicsD. magna CT448 protease specificity
Mass developments of toxin-producing cyanobacteria are frequently observed in freshwater ecosystems due to eutrophication and global warming. These mass developments can partly be attributed to cyanobacterial toxins, such as protease inhibitors (PIs), which inhibit digestive serine proteases of Daph...
ORGANISM(S): Daphnia magna 
2018-10-04 | PXD010978 | Pride
Ct448 pics protease specificity 
UnknownAlterations in the Metabolic and Lipid Profiles Associated with Vitamin D Deficiency in Early Pregnancy.
Not available
S-EPMC12526048 | biostudies-literature
ProteomicsThe AMBRA1 E3 ligase adaptor regulates Cyclin D protein stability
Here we describe AMBRA1 as the main regulator of Cyclin D protein degradation. We first identify AMBRA1 as the top candidate in a genome-wide CRISPR/Cas9 loss-of-function screen investigating the genetic basis of resistance to chemical CDK4/6 inhibition. AMBRA1 loss results in high protein levels of...
ORGANISM(S): Homo sapiens (Human) 
2021-07-24 | PXD021789 | Pride
Human Cancer Cyclin d Cell cycle 
UnknownExposure single-cell metabolomics mass spectrometry reveals HFPO-DA toxicity mechanisms.
Not available
S-EPMC12817909 | biostudies-literature
UnknownPrediagnostic Plasma 25-Hydroxyvitamin D and Pancreatic Cancer Survival.
Not available
S-EPMC5012662 | biostudies-literature
ProteomicsDECA, a comprehensive, automatic post-processing program for HDX-MS data
Data from the following publication: D. Narang, W. Chen, C. G. Ricci, E. A. Komives, RelA-Containing NFkappaB Dimers Have Strikingly Different DNA-Binding Cavities in the Absence of DNA. Journal of molecular biology 430, 1510-1520 (2018). Used as sample dataset for manuscript.
ORGANISM(S): Human 
2019-08-12 | MSV000084200 | MassIVE
MetabolomicsStudy on the Effect of Bee Venom and Its Main Component melittin In Delaying Skin Aging in Mice
Bee venom (BV) and its main compound melittin (MLT) have antioxidant, anti-inflammatory, and anti-aging activities; however, very little research has been conducted on their effects on skin aging. In this study, a mouse skin aging model induced by D-galactose (D-gal) was constructed via subcutaneous...
2025-05-12 | MTBLS11975 | MetaboLights
ProteomicsIdentification of Cytosolic Protein Targets of Catechol Estrogens in Breast Cancer Cells Using a Click Chemistry-based Workflow
Catechol estrogens (CEs) are known to be toxic metabolites and the initiators in the oncogenesis of breast cancers via forming covalent adducts with DNAs. CEs shall also react with proteins but their cellular protein targets remain un-explored. Here we reported the identification of protein targets ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD017731 | Pride
Affinity purification Catechol estrogens Breast cancer cells Mass spectrometry Proteomic 
UnknownMarine-Derived Bioactive Peptides Self-Assembled Multifunctional Materials: Antioxidant and Wound Healing.
Not available
S-EPMC10295045 | biostudies-literature
TranscriptomicsRNA-Seq dependent transcriptional analysis unveils adaptive mechanisms in the intestine of sea cucumber Apostichopus japonicus during aestivation
Sea cucumbers (Holothuroidea; Echinodermata), cycle annually between aestivation when water temperature is above about 25°C in the summer and active life when temperature is below about 18°C. We used RNA-Seq to determine gene expression profiles of intestine tissue of A.japonicus during non-aestivat...
ORGANISM(S): Apostichopus japonicus 
2015-08-08 | E-GEOD-51137 | biostudies-arrayexpress
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