Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse transition from normal intestine to adenoma in the apc(min/+) mouse
Transcriptional Profiling of the Transition from Normal Intestine to Adenoma in the APC(Min/+) Mouse. Tissue was from male 91-days old APC(Min/+) mouse (an animal model for human colon cancer). RNA was purified using Trizol and labeled for hybridization to high density oligonucleotide Affymetrix MG_...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-784 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of novel antigen presenting cells (APC) inducing pathogenic T helper cells of lupus
In lupus autoimmunity, pathogenic IgG autoantibodies that fix complement and bind FcGammaR on inflammatory cells, are produced with help from T helper (Th1 and Th17) cells specific for peptides from nucleosomes of apoptotic cells; and these Th cells also infiltrate vital organs (1-9). Macrophages (...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36284 | biostudies-arrayexpress
TranscriptomicsColon tumor samples
In response to polarization cues, cultured Caco-2 cells, a human colon adenocarcinoma-derived cell line, form a polarized epithelium resembling normal enterocytes. We investigated potential signaling mechanisms activated by Caco-2 cells that might trigger the genome-wide transcriptional reprogrammi...
ORGANISM(S): Homo sapiens 
2007-08-17 | E-GEOD-7466 | biostudies-arrayexpress
TranscriptomicsPLA2G2A and human gastric cancers
We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing approximately 30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc(Min/+) (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly corr...
ORGANISM(S): Homo sapiens 
2006-01-10 | E-GEOD-4007 | biostudies-arrayexpress
TranscriptomicsEffect of retinoic acid on gene expression in CD4 cells stimulated with anti CD3 and CD28
RNA extracted from CD4 cells was analyzed using affymetrix gene array chips.Data set includes analysis of RNA from DMSO or ATRA treated samples. ATRA induced the expression of a number of genes including LZTFL1. Retinoic acids, which are metabolites of vitamin A, have been shown to be involved in m...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-74280 | biostudies-arrayexpress
TranscriptomicsEctopic Expression data of TLX1 in Hematopoietic Progenitors in TLX1 Transgenic Mice Deficient in DNA-PK
The noncluster homeodomain containing gene, HOX11/TLX1 (TLX1) is detected at the breakpoint of the t(10;14)(q24;q11) chromosome translocation in patients with T cell Acute Lymphoblastic leukemia (T-ALL). This translocation results in the inappropriate expression of TLX1 in T cells. The oncogenic pot...
ORGANISM(S): Mus musculus 
2014-04-05 | E-GEOD-47421 | biostudies-arrayexpress
TranscriptomicsCell type-specific requirements for iPSC reprogramming
The differentiated state of somatic cells provides barriers for the efficient derivation of induced pluripotent stem cells (iPSCs). To address why some cell types reprogram more readily than others, we studied the effect of combined modulation of cellular signaling pathways. This revealed that inhib...
ORGANISM(S): Mus musculus 
2014-09-11 | E-GEOD-59865 | biostudies-arrayexpress
TranscriptomicsArray comparative genomic hybridization analysis of flat epithelial atypia (DIN1a) and lobular intraepithelial neoplasia
Low grade flat ductal intraepithelial neoplasia (DIN1a, flat epithelial atypia) is one of the earliest morphologically recognizable neoplastic lesions of the breast. Frequently, it occurs in association with lobular intraepithelial neoplasia (LIN). The aim of this study was to elucidate chromosomal ...
ORGANISM(S): Homo sapiens 
2010-05-05 | E-GEOD-18187 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of cKIT+ sorted cells from 53-137 day old fetal testes and ovaries and RNA-Seq of TRA-1-81+ H1 and UCLA1 hESCs.
We performed RNA-Seq analyses on 15 human fetal samples at 53-137 days of development, 9 female and 5 male, and identified the transcriptional changes during the transition of human cKIT+ primordial germ cells (PGCs), the precursors of gametes, to the generation of Advanced Germline Cells. Comparing...
ORGANISM(S): Homo sapiens 
2015-05-28 | E-GEOD-63392 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of cKIT+ sorted cells from 16-16.5 week old fetal testes and ovaries and RNA-Seq of TRA-1-60+ H1 hESCs
Generation of research quality, clinically relevant cell types in vitro from human pluripotent stem cells (hPSCs) requires detailed understanding of the equivalent cell types in humans. Here we analyzed 130 human fetal samples at 6-20 weeks of development and identified the stages in which human cKI...
ORGANISM(S): Homo sapiens 
2012-08-03 | E-GEOD-39821 | biostudies-arrayexpress
Sort   by:  
 Page size