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TranscriptomicsAnalysis of gene expression in JAK2 exon 12-mutant erythroblasts
For 13 patients with JAK2 exon 12-mutated polycythemia vera (PV), we compared genome-wide RNA profiles of JAK2-mutant (mutant) and wild-type erythroid colonies, grown from a single patient in the same culture plate. This paired approach controls for factors including age, gender, treatment, germline...
ORGANISM(S): Homo sapiens 
2015-10-04 | E-MTAB-3946 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of normal and JAK2V617F-positive erythroblasts of polycythemia vera and essential thrombocythemia
This experiment was designed to identify genes differentially expressed in association with the JAK2V617F mutation in polycythemia vera (PV) and essential thrombocythemia (ET). Peripheral blood was obtained from 20 ET and 16 PV patients and erythroid progenitors were grown in semi-solid methylcellul...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-MTAB-384 | biostudies-arrayexpress
UnknownQuantum dot/antibody conjugates for in vivo cytometric imaging in mice.
Not available
S-EPMC4321304 | biostudies-literature
TranscriptomicsDevelopment and Plasticity of Alveolar Type 1 Cells
The alveolar type 1 (AT1) cell covers >95% of the gas exchange surface and is extremely thin to facilitate passive gas diffusion. The development of this highly specialized cell is poorly understood including fundamental questions regarding cell number and morphology. Using new molecular stereology ...
ORGANISM(S): Mus musculus 
2015-12-08 | E-GEOD-73861 | biostudies-arrayexpress
UnknownIntegrating Ataxia Evaluation into Tumor-Induced Hearing Loss Model to Comprehensively Study NF2-Related Schwannomatosis.
Not available
S-EPMC11171041 | biostudies-literature
TranscriptomicsTranscription profiling of Drosophila antennal, eye, leg and wing discs with wild type or eyeless ectopic expression
The discovery of direct downstream targets of transcription factors (TFs) is necessary for understanding the genetic mechanisms underlying complex, highly regulated processes such as development. In this report, we have used a combinatorial strategy to conduct a genome-wide search for novel direct ...
ORGANISM(S): Drosophila melanogaster 
2007-09-28 | E-GEOD-4008 | biostudies-arrayexpress
UnknownPhase II Study of Allogeneic Transplantation for Older Patients With Acute Myeloid Leukemia in First Complete Remission Using a Reduced-Intensity Conditioning Regimen: Results From Cancer and Leukemia Group B 100103 (Alliance for Clinical Trials in Oncology)/Blood and Marrow Transplant Clinical Trial Network 0502.
Not available
S-EPMC4658453 | biostudies-literature
TranscriptomicsGene expression profiling to study the transcriptional consequences of Jak2V617F expression and/or Tet2 loss in murine hematopoietic stem cells
To interrogate the molecular pathways disrupted by Jak2V617F expression and/or Tet2 loss, Lin-negative, Sca-1-positive, c-kit-positive (LSK) hematopoietic progenitor cells were isolated from bone marrow of wild-type, Jak2V617F, Tet2-null or Jak2V617F/Tet2-null animals (n= 2-4 mice per group) and sub...
ORGANISM(S): Mus musculus 
2014-10-31 | E-MTAB-2986 | biostudies-arrayexpress
ProteomicsAndrogen receptor RIME in prostate cancer cells
Androgen receptor (AR) is a master transcription factor that drives prostate cancer (PCa) development and progression. Alterations in the expression or activity of AR coregulators significantly impact the disease's outcome. To identify all the essential components of the AR coregulator complex, we u...
ORGANISM(S): Homo sapiens (Human) 
2022-07-12 | PXD031273 | Pride
Androgen receptor Prostate cancer Rime Cofactors 
UnknownDual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma.
Not available
S-EPMC7000304 | biostudies-literature
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